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| The Research Progress of Transcranial Direct Current Stimulation in the Treatment of Alzheimer′s Disease |
| Luo Yinpei1, Li Nian1, Wen Huizhong2*, Tian Xuelong1* |
1(School of Bioengineering, Chongqing University, Chongqing 400044, China)
2(Department of Neurobiology, College of Basic Medical Sciences, Army Medical University, Chongqing Key Laboratory of Neurobiology, Chongqing 400038, China) |
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Abstract Alzheimer′s disease (AD) is an irreversible neurodegenerative disease that seriously affects the physical and mental health and daily activities of patients. It is currently not possible to effectively prevent the course of AD through drug and cognitive training. Transcranial direct current stimulation (tDCS) is a non-invasive neuromodulation technique that is safe, economical, and well tolerated. It has been widely used in many studies of neurodegenerative diseases in recent years. Studies have found out that tDCS can improve learning and memory and cognitive dysfunction in AD patients by regulating synaptic accessibility, participating in inflammation regulation and regulating local blood flow. Therefore, tDCS is a very promising treatment for AD. In order to better understand and promote the application of tDCS in AD, this paper reviewed the application status and mechanisms of tDCS in AD.
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Received: 20 December 2018
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[1] Molteni M, Rossetti C. Neurodegenerative diseases: The immunological perspective [J]. Journal of Neuroimmunology, 2017, 313: 109-115.
[2] Patterson C. World Alzheimer Report 2018 [R]. 2018.
[3] Blennow K, de Leon MJ, Zetterberg H. Alzheimer′s disease [J]. Lancet, 2006, 368(9533): 387-403.
[4] Mielkea MM, Corcoran CD, Green RC, et al. Effects of Food and Drug Administration-approved medications for Alzheimer′s disease on clinical progression [J]. Alzheimers & Dementia, 2012, 8(3): 180-187.
[5] Godyń J, Jończyk J, Panek D, et al. Therapeutic strategies for Alzheimer's disease in clinical trials [J]. Pharmacological Reports, 2016, 68(1): 127-138.
[6] Aldini J. Essai théorique et expérimental sur le galvanisme, avec une série d’expériences faites devant des commissaires de l’Institut national de France, et en divers amphithéâtres anatomiques de Londres [D]. Paris: Fournier Fils, 1804.
[7] Kristin P, Agnes F. Potentials and limits to enhance cognitive functions in healthy and pathological aging by tDCS [J]. Frontiers in Cellular Neuroscience, 2015, 9: 355.
[8] Purpura DP, McMurtry JG. Intracellular activities and evoked potential changes during polarization of motor cortex [J]. Journal of Neurophysiology, 1965, 28(28): 166-185.
[9] Stagg CJ, Antal A, Nitsche MA, et al. Physiology of Transcranial Direct Current Stimulation [J]. Journal of Ect, 2018, 34(3): 144-152.
[10] Elder GJ, Taylor J. Transcranial magnetic stimulation and transcranial direct current stimulation: treatments for cognitive and neuropsychiatric symptoms in the neurodegenerative dementias? [J]. Alzheimer's Research & Therapy, 2014, 6(9): 74-74.
[11] Pellicciari MC, Miniussi C. Transcranial Direct Current Stimulation in Neurodegenerative Disorders [J]. Journal of Ect, 2018, 34(3): 193-202.
[12] Tortella G, Casati R, Aparicio LV, et al. Transcranial direct current stimulation in psychiatric disorders [J]. World Journal of Psychiatry, 2015, 5(1): 88-102.
[13] Cotelli M, Manenti R, Brambilla M, et al. Anodal tDCS during face-name associations memory training in Alzheimer's patients [J]. Frontiers in Aging Neuroscience, 2014, 6: 38.
[14] Bystad M, Gronli O, Rasmussen ID, et al. Transcranial direct current stimulation as a memory enhancer in patients with Alzheimer′s disease: a randomized, placebo-controlled trial [J]. Alzheimers Research & Therapy, 2016, 8(1): 13-13.
[15] Bystad M, Rasmussen ID, Ole Grønli, et al. Can 8 months of daily tDCS application slow the cognitive decline in Alzheimer′s disease? A case study [J]. Neurocase, 2017, 23(2): 1-3.
[16] Boggio PS, Khoury LP, Martins DCS, et al. Temporal cortex direct current stimulation enhances performance on a visual recognition memory task in Alzheimer disease [J]. Journal of Neurology, Neurosurgery, and Psychiatry, 2009, 80(4): 444-447.
[17] Boggio PS, Ferrucci R, Mameli F, et al. Prolonged visual memory enhancement after direct current stimulation in Alzheimer's disease [J]. Brain Stimulation, 2012, 5(3): 223-230.
[18] Costa V, Brighina F, Piccoli T, et al. Anodal transcranial direct current stimulation over the right hemisphere improves auditory comprehension in a case of dementia [J]. NeuroRehabilitation, 2017, 41(2): 567-575.
[19] Ferrucci R, Mameli F, Guidi I, et al. Transcranial direct current stimulation improves recognition memory in Alzheimer disease [J]. Neurology, 2008, 71(7): 493-498.
[20] Khedr EM, Gamal NFE, El-Fetoh NA, et al. A double-blind randomized clinical trial on the efficacy of cortical direct current stimulation for the treatment of Alzheimer′s disease [J]. Frontiers in Aging Neuroscience, 2014, 6(275): 275.
[21] Andrade SM, Fernandezcalvo B, Araújo RCN, et al. Adjuvant transcranial direct current stimulation for treating Alzheimer′s disease: A case study [J]. Dementia & Neuropsychologia, 2016, 10(2): 156-159.
[22] Parra MA, Ascencio LL, Urquina HF, et al. P300 and neuropsychological assessment in mild cognitive impairment and Alzheimer dementia [J]. Frontiers in Neuroscience, 2012, 3: 172.
[23] Hsu WY, Ku Y, Zanto TP, et al. Effects of noninvasive brain stimulation on cognitive function in healthy aging and Alzheimer′s disease: a systematic review and meta-analysis [J]. Neurobiology of Aging, 2015, 36(8): 2348-2359.
[24] Bindman LJ, Lippold OCJ, Redfearn JWT. Long-lasting changes in the level of the electrical activity of the cerebral cortex produced by polarizing currents [J]. Nature, 1962, 196(4854): 584-585.
[25] Nitsche MA, Paulus W. Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation [J]. Journal of Physiology, 2000, 527(3): 633-639.
[26] Marceglia S, Mrakicsposta S, Rosa M, et al. Transcranial direct current stimulation modulates cortical neuronal activity in Alzheimer's disease [J]. Frontiers in Neuroscience, 2016, 10(83):134.
[27] Wiethoff S, Hamada M, Rothwell JC, et al. Variability in response to transcranial direct current stimulation of the motor cortex [J]. Brain Stimulation, 2014, 7(3): 468-475.
[28] Batsikadze G, Moliadze V, Paulus W, et al. Partially non-linear stimulation intensity-dependent effects of direct current stimulation on motor cortex excitability in humans [J]. The Journal of Physiology, 2013, 591(7): 1987-2000.
[29] Yu Xuehong, Li Yiyan, Wen Huizhong, et al. Intensity-dependent effects of repetitive anodal transcranial direct current stimulation on learning and memory in a rat model of Alzheimer's disease [J]. Neurobiology of Learning & Memory, 2015, 123: 168-178.
[30] Nitsche MA, Paulus W. Sustained excitability elevations induced by transcranial DC motor cortex stimulations in humans [J]. Neurology, 2001, 57(10): 1899-1901.
[31] Maeda K, Maruyama R, Nagae T, et al. Weak sinusoidal electric fields entrain spontaneous Ca transients in the dendritic tufts of CA1 pyramidal cells in rat hippocampal slice preparations [J]. PLOS ONE, 2015, 10(3): 1271-1274.
[32] Suemoto CK, Apolinario D, Nakamurapalacios EM, et al. Effects of a non-focal plasticity protocol on apathy in moderate Alzheimer's disease: A randomized, double-blind, sham-controlled trial [J]. Brain Stimulation, 2014, 7(2): 308-313.
[33] Penolazzi B, Bergamaschi S, Pastore M, et al. Transcranial direct current stimulation and cognitive training in the rehabilitation of Alzheimer disease: A case study [J]. Neuropsychological Rehabilitation, 2015, 25(6): 799-817.
[34] Burton N, Jeffery L, Bonner J, et al. The timecourse of expression after effects [J]. Journal of Vision, 2016, 16(15): 1-12.
[35] Gonzalez PC. Can transcranial direct-current stimulation alone or combined with cognitive training be used as a clinical intervention to improve cognitive functioning in persons with mild cognitive impairment and dementia? A systematic review and meta-analysis [J/OL].https://doi.org/10.3389/fnhum.2018.00416,2018-10-16/2018-12-22.
[36] Horvath JC, Forte JD, Carter O, et al. Quantitative review finds no evidence of cognitive effects in healthy populations from single-session transcranial direct current stimulation (tDCS) [J]. Brain Stimulation, 2015, 8(3): 535-550.
[37] Yu SH, Park SD, Sim KC. The effect of tDCS on cognition and neurologic recovery of rats with Alzheimer′s disease [J]. Journal of Physical Therapy Science, 2014, 26(2): 247-249.
[38] 俞雪鸿, 温惠中, 张运明, 等. 重复经颅直流电刺激对阿尔茨海默大鼠学习记忆能力的影响 [J]. 第三军医大学学报, 2015, 37(5): 449-453.
[39] 周露旭. 经颅直流电刺激对AD大鼠治疗的后效及生理电变化探究 [D]. 重庆:重庆大学,2017.
[40] Dedoncker J, Brunoni AR, Baeken C, et al. A systematic review and meta-analysis of the effects of transcranial direct current stimulation (tdcs) over the dorsolateral prefrontal cortex in healthy and neuropsychiatric samples: Influence of stimulation parameters [J]. Brain Stimulation, 2016, 9(4): 501-517.
[41] Kumar S, Zomorrodi R, Ghazala Z, et al. Extent of dorsolateral prefrontal cortex plasticity and its association with working memory in patients with Alzheimer disease [J]. JAMA Psychiatry, 2017, 74(12): 1266-1274.
[42] Spaniol J, Davidson PSR, Kim ASN, et al. Event-related fMRI studies of episodic encoding and retrieval: Meta-analyses using activation likelihood estimation [J]. Neuropsychologia, 2009, 47(8-9):1765-1779.
[43] Fregni F, Boggio PS, Nitsche M, et al. Anodal transcranial direct current stimulation of prefrontal cortex enhances working memory [J]. Experimental Brain Research, 2005, 166(1): 23-30.
[44] Manenti R, Brambilla M, Petesi M, et al. Enhancing verbal episodic memory in older and young subjects after non-invasive brain stimulation [J]. Frontiers in Aging Neuroscience, 2013, 5(10):49.
[45] Dickerson BC, Sperling RA. Functional abnormalities of the medial temporal lobe memory system in mild cognitive impairment and Alzheimer's disease: insights from functional MRI studies [J]. Neuropsychologia, 2008, 46(6): 1624-1635.
[46] Rémy F, Mirrashed F, Campbell B, et al. Verbal episodic memory impairment in Alzheimer's disease: a combined structural and functional MRI study [J]. Neuroimage, 2005, 25(1): 253-266.
[47] Yuan H, Tabarak S, Yu J, et al. Transcranial direct current stimulation in patients with Alzheimer′s disease: Challenges and responses [J]. ADMET and DMPK, 2015, 3(3): 235-241.
[48] Liu CS, Rau A, Gallagher D, et al. Using transcranial direct current stimulation to treat symptoms in mild cognitive impairment and Alzheimer's disease [J]. Neurodegenerative Disease Management, 2017, 7(5): 317-329.
[49] Kessler SK, Minhas P, Woods AJ, et al. Dosage considerations for transcranial direct current stimulation in children: a computational modeling study [J]. PLOS ONE, 2013, 8(9):e76112.
[50] Berryhill ME, Jones KT. tDCS selectively improves working memory in older adults with more education [J]. Neuroscience Letters, 2012, 521(2): 148-151.
[51] Wagner TA, Valerocabre A, Pascualleone A, et al. Noninvasive human brain stimulation [J]. Annual Review of Biomedical Engineering, 2007, 9(1): 527-565.
[52] Knotkova H, Rasche D. Textbook of neuromodulation: principles, methods and clinical applications [M]// Transcranial Direct Current Stimulation: Protocols and Physiological Mechanisms of Action. New York: Springer New York, 2015: 101-111.
[53] Liebetanz D, Koch R, Mayenfels S, et al. Safety limits of cathodal transcranial direct current stimulation in rats [J]. Clinical Neurophysiology, 2009, 120(6): 1161-1167.
[54] Agnew WF, Mccreery DB. Considerations for safety in the use of extracranial stimulation for motor evoked potentials [J]. Neurosurgery, 1987, 20(1): 143-147.
[55] Rush S, Driscoll DA. Current distribution in the brain from surface electrodes [J]. Anesthesia & Analgesia, 1968, 47(6): 717-723.
[56] Nitsche MA, Niehaus L, Hoffmann KT, et al. MRI study of human brain exposed to weak direct current stimulation of the frontal cortex [J]. Clinical Neurophysiology, 2004, 115(10): 2419-2423.
[57] Poreisz C, Boros K, Antal A, et al. Safety aspects of transcranial direct current stimulation concerning healthy subjects and patients [J]. Brain Research Bulletin, 2007, 72(4): 208-214.
[58] Loo CK, Martin DM. Special issue on transcranial direct current stimulation [J]. Journal of Ect, 2018, 34(3): 135-136.
[59] Kanaan SF, Mcdowd JM, Colgrove YM, et al. Feasibility and efficacy of intensive cognitive training in early-stage Alzheimer′s disease [J]. American Journal of Alzheimers Disease and Other Dementias, 2014, 29(2): 150-158.
[60] Ditye T, Jacobson L, Walsh V, et al. Modulating behavioral inhibition by tDCS combined with cognitive training [J]. Experimental Brain Research, 2012, 219(3): 363-368.
[61] Park S, Seo J, Kim Y, et al. Long-term effects of transcranial direct current stimulation combined with computer-assisted cognitive training in healthy older adults [J]. Neuroreport, 2014, 25(2): 122-126.
[62] Petersen RC, Lopez O, Armstrong MJ, et al. Practice guideline update summary: Mild cognitive impairment: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology [J]. Neurology, 2018, 90(3): 126-135.
[63] Grundman M, Petersen RC, Ferris SH, et al. Mild cognitive impairment can be distinguished from Alzheimer disease and normal aging for clinical trials [J]. Archives of Neurology, 2004, 61(1): 59-66.
[64] Alzheimer′s Association. 2018 Alzheimer′s disease facts and figures [J]. Alzheimer′s & Dementia, 2018, 14(3): 367-429.
[65] Ward A, Tardiff S, Dye C, et al. Rate of conversion from prodromal Alzheimer's disease to Alzheimer's dementia: A systematic review of the literature [J]. Dementia & Geriatric Cognitive Disorders Extra, 2013, 3(1): 320-332.
[66] Meinzer M, Lindenberg R, Phan MT, et al. Transcranial direct current stimulation in mild cognitive impairment: Behavioral effects and neural mechanisms [J]. Alzheimers & Dementia, 2015, 11(9): 1032-1040.
[67] Yun K, Song IU, Chung YA, et al. Changes in cerebral glucose metabolism after 3 weeks of noninvasive electrical stimulation of mild cognitive impairment patients [J]. Alzheimer′s Research & Therapy, 2016, 8(1): 49-49.
[68] Ladenbauer J, Ladenbauer J, Kulzow N, et al. Promoting sleep oscillations and their functional coupling by transcranial stimulation enhances memory consolidation in mild cognitive impairment [J]. The Journal of Neuroscience, 2017, 37(30): 7111-7124.
[69] Murugaraja V, Shivakumar V, Sivakumar PT, et al. Clinical utility and tolerability of transcranial direct current stimulation in mild cognitive impairment [J]. Asian Journal of Psychiatry, 2017, 30: 135-140.
[70] Gonzalez PC, Fong KN, Brown T, et al. The effects of transcranial direct current stimulation on the cognitive functions in older adults with mild cognitive impairment: A pilot study [J]. Behavioural Neurology, 2018, 2018: 1-14.
[71] Manenti R, Sandrini M, Gobbi E, et al. Effects of transcranial direct current stimulation on episodic memory in amnestic mild cognitive impairment: A pilot study [J]. The Journals of Gerontology, 2018, 29(2):657-665.
[72] Kidgell DJ, Goodwill AM, Frazer AK, et al. Induction of cortical plasticity and improved motor performance following unilateral and bilateral transcranial direct current stimulation of the primary motor cortex [J]. BMC Neuroscience, 2013, 14(1): 64-64.
[73] Albert DJ. The effect of spreading depression on the consolidation of learning [J]. Neuropsychologia, 1966, 4(1): 0-64.
[74] Hebb, The rganization of behavior [M]. New York: Wiley & Sons, 1949.
[75] Bliss TV, Lomo T. Long-lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path [J]. The Journal of Physiology, 1973, 232(2): 331-356.
[76] Martin SJ, Grimwood PD, Morris RGM. Synaptic plasticity and memory: an evaluation of the hypothesis [J]. Annual Review of Neuroscience, 2000, 23(1): 649-711.
[77] Clements MP, Bliss TV, Lynch MA. A synaptic model of memory: long-term potentiation in the hippocampus [J]. Nature, 1993, 361(6407): 31-39.
[78] Stagg CJ, Best JG, Stephenson MC, et al. Polarity-sensitive modulation of cortical neurotransmitters by transcranial stimulation [J]. Journal of Neuroscience, 2009, 29(16): 5202-5206.
[79] Stagg CJ, Nitsche MA. Physiological basis of transcranial direct current stimulation [J]. Neuroscientist, 2011, 17(1): 37-53.
[80] Fritsch B, Reis J, Martinowich K, et al. Direct current stimulation promotes BDNF-dependent synaptic plasticity: Potential implications for motor learning [J]. Neuron, 2010, 66(2): 198-204.
[81] Zhengyan J. Abnormal cortical functional connections in Alzheimer′s disease: analysis of inter-and intra-hemispheric EEG coherence [J]. Journal of Zhejiang University-science B, 2005, 6(4): 259-264.
[82] Vecchio F, Miraglia F, Quaranta D, et al. Cortical connectivity and memory performance in cognitive decline: A study via graph theory from EEG data [J]. Neuroscience, 2016, 316: 143-150.
[83] Heneka MT, Kummer MP, Stutz A, et al. NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice [J]. Nature, 2012, 493(7434): 674-678.
[84] Venegas C, Kumar S, Franklin BS, et al. Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer′s disease [J]. Nature, 2017, 552(7685): 355-361.
[85] Ulland TK, Song W, Huang SC, et al. TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease [J]. Cell, 2017, 170(4): 649-663.
[86] Verkhratsky A, Olabarria M, Noristani HN, et al. Astrocytes in Alzheimer′s disease [J]. Neurotherapeutics, 2010, 7(4): 399-412.
[87] Ruohonen J, Karhu J. tDCS possibly stimulates glial cells [J]. Clinical Neurophysiology, 2012, 123(10): 2006-2009.
[88] Pikhovych A, Rueger MA, Graf R, et al. Transcranial direct current stimulation modulates neurogenesis and microglia activation in the mouse brain [J]. Stem Cells International, 2016, 2016: 1-9.
[89] Dutta A, Jacob A, Chowdhury SR, et al. EEG-NIRS based assessment of neurovascular coupling during anodal transcranial direct current stimulation - A stroke case series [J]. Journal of Medical Systems, 2015, 39(4): 1-9.
[90] Pulgar VM. Direct electric stimulation to increase cerebrovascular function [J]. Front Syst Neurosci, 2015, 9(54): 54.
[91] Hansen N. Action mechanisms of transcranial direct current stimulation in Alzheimer′s disease and memory loss [J]. Frontiers in Psychiatry, 2012, 3: 48.
[92] Lang N, Siebner HR, Ward NS, et al. How does transcranial DC stimulation of the primary motor cortex alter regional neuronal activity in the human brain [J]. European Journal of Neuroscience, 2005, 22(2): 495-504.
[93] Merzagora AC, Foffani G, Panyavin I, et al. Prefrontal hemodynamic changes produced by anodal direct current stimulation [J]. Neuroimage, 2010, 49(3): 2304-2310.
[94] Zheng X, Alsop DC, Schlaug G. Effects of transcranial direct current stimulation (tDCS) on human regional cerebral blood flow [J]. Neuroimage, 2011, 58(1): 26-33.
[95] Wachter D, Wrede A, Schulzschaeffer WJ, et al. Transcranial direct current stimulation induces polarity-specific changes of cortical blood perfusion in the rat [J]. Experimental Neurology, 2011, 227(2): 322-327.
[96] Hampstead B, Gopinath K. Behavioral and fMRI changes associated with combined tDCS and cognitive rehabilitation in a case series of patients with mild cognitive impairment [J]. Clinical Neurophysiology, 2013, 124(10): e123-e124.
[97] Van Beek AH, Lagro J, Olderikkert M, et al. Oscillations in cerebral blood flow and cortical oxygenation in Alzheimer′s disease [J]. Neurobiology of Aging, 2012, 33(2): 4-8.
[98] Polania R, Nitsche MA, Paulus W, et al. Modulating functional connectivity patterns and topological functional organization of the human brain with transcranial direct current stimulation [J]. Human Brain Mapping, 2011, 32(8): 1236-1249.
[99] Meinzer M, Antonenko D, Lindenberg R, et al. Electrical brain stimulation improves cognitive performance by modulating functional connectivity and task-specific activation [J]. The Journal of Neuroscience, 2012, 32(5): 1859-1866.
[100] Zhao Y, Jaber V, Lukiw WJ, et al. Secretory products of the human gi tract microbiome and their potential impact on Alzheimer's disease (AD): Detection of lipopolysaccharide (LPS) in AD hippocampus [J]. Frontiers in Cellular and Infection Microbiology, 2017, 7: 318.
[101] Zhan X, Stamova B, Jin LW, et al. Gram-negative bacterial molecules associate with Alzheimer disease pathology [J]. Neurology, 2016, 87(22): 2324-2332.
[102] Sandin L, Bergkvist L, Nath S, et al. Beneficial effects of increased lysozyme levels in Alzheimer′s disease modelled in Drosophila melanogaster [J]. FEBS Journal, 2016, 283(19): 3508-3522. |
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