经颅直流电刺激对孤独症谱系障碍儿童脑电的影响研究

doi:10.3969/j.issn.0258-8021.2019.05.007

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Abstract The autism spectrum disorder (ASD) is a complex developmental disorder characterized by impairments of social communication and repetitive behaviors. Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that can be conducted on many neuropsychiatric and neurological disorders such as epilepsy, Parkinson’s disease, Alzheimer’s disease, major depression and schizophrenia. It is safe and easy-to-use, because thousands of tDCS sessions have been reported without any serious adverse effects. In this study, we enrolled 24 ASD children who received transcranial direct current stimulation (tDCS) brain modulation. Among those, 12 ASD children received 10 treatments over the dorsolateral prefrontal cortex (DLPFC) twice a week and the other 12 ASD children received sham-stimulation twice a week as controls. Power spectrum and multiscale entropy algorithm were used to evaluate the effects. Results showed that 4~8 Hz theta band decreased significantly (P<0.05) in the whole brain before and after intervention, the frontal lobe decreased from (1.13±0.07) dB/Hz to (0.96±0.06)dB/Hz, from (1.18±0.05) dB/Hz to (1.03±0.07)dB/Hz in the left temporal lobe, from (1.43±0.06) dB/Hz to (1.16±0.03)dB/Hz in the central region, from (1.14±0.09) dB/Hz to (0.96±0.04)dB/Hz in the right temporal lobe, and from (1.39±0.06) dB/Hz to (1.09±0.03)dB/Hz in the occipital lobe. Entropy values in parietal lobe (P3, Pz, C3, C4), occipital lobe (O1) and DLPFC (F3) were significantly increased by calculating the entropy values at 15 scales after intervention. The tDCS had positive effects on the autistic children and it was safe and non-invasive, therefore it would be helpful for the rehabilitation of autistic children.

Key words： autism spectrum disorder(ASD) transcranial direct current stimulation(tDCS) power spectrum multiscale entropy(MSE)

Received: 25 July 2018

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R318

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	Articles by authors
	Wen Fang
	Pang Jiao
	Li Xiaoli
	Kang Jiannan

Cite this article:

Wen Fang,Pang Jiao,Li Xiaoli, et al. Research on Effects of Transcranial Direct Current Stimulation on EEG in Children with Autism Spectrum Disorder[J]. Chinese Journal of Biomedical Engineering, 2019, 38(5): 566-572.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2019.05.007 OR http://cjbme.csbme.org/EN/Y2019/V38/I5/566

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