抑郁症情绪面孔加工的大脑功能网络研究

doi:10.3969/j.issn.0258-8021. 2014. 05.06

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Abstract The present study investigated whether functional brain networks are abnormally organized in the depression under the emotional stimuli. We applied phase synchronization to construct the connectivity and global and local efficiency to explore the smallworld topology of the brain networks. Sixteen depressed patients and fourteen healthy subjects participated in the study, with the continuous scalp electroencephalography (EEG) collected. We constructed the phase synchronization matrices using the EEG in low gamma (30～50 Hz) and high gamma (50～80 Hz) bands. We found the global phase synchronization values of depressed group are significantly higher than healthy controls. When costs were between 025 and 050 in low gamma band and between 025 and 055 in high gamma band, global and local efficiency of brain networks were between random graph and lattice, indicating the smallworld networks. When costefficiency reached maximum (cost equaled to 03) in high gamma band, global efficiency had significant differences between groups, without findings on local efficiency. When cost equaled to 05, abnormal activities were found in the left temporalparietal and occipital region. Results reflected the abnormal network features in depression under emotional processing by the measures of global and local efficiency and provided a reference for researches on neural networks in depression.

Key words： depression EEG smallworld network efficiency

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	GAO Yun CAO Dan LI Ying Jie ^#*

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GAO Yun CAO Dan LI Ying Jie ^#*. Brain Functional Network of Depression during Facial Emotional Processing#br#[J]. journal1, 2014, 33(5): 556-563.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021. 2014. 05.06 OR http://cjbme.csbme.org/EN/Y2014/V33/I5/556

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