rTMS联合运动训练对静息态脑网络影响的研究

doi:10.3969/j.issn.0258-8021.2018.03.005

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Abstract It was reported that repetitive transcranial magnetic stimulation (rTMS) combined with motor training could improve the motor skill, which could be used in motor rehabilitation after stroke. In this study, the effects of rTMS combined with motor training on brain neural activities were investigated based on the method of brain network. Ten healthy volunteers were recruited. The 1 Hz rTMS over the dominant hemisphere combined with unfamiliar motor training with non-dominant hand subsequently was performed rTMS combined with motor training lasted 14 days to improve the motor function of non-dominant hand. Electroencephalography (EEG) in resting state with eyes closed was recorded before and after rTMS combined with motor training. The functional connectivity was analyzed using the method of phase lag index (PLI). We constructed weighted network and calculated the network topology characteristics based on PLI, subsequently. Finally, the signed-rank test was used for statistical analysis. We found that the changes of functional connectivity could be detected mainly between functional regions rather than inside regions. The functional connectivity at lower frequency band (theta and alpha) was significantly increased, and was opposite at higher frequency band (beta, gamma₁ and gamma₂). Furthermore, we found that the rTMS combined with motor training had a significant influence on the functional connectivity between central region in non-dominant hemisphere and dominant frontal regions (before: 0.141 4±0.102 5;after:0.217 2±0.134 7; P<0.05) and non-dominant frontal regions(before:0.141 0±0.109 9;after:0.205 9±0.136 1; P <0.05) at alpha frequency. Node efficiency increased at low band and decreased at high band, and node path length was opposite. Specifically, the node efficiency at gamma₂ bandchanged significantly, mainly in central regions of both hemisphere (left, before: 0.060 0±0.000 3; after: 0.042 9±0.001 3; P <0.05; right, before: 0.060 7±0.002 3; after: 0.041 9±0.002 4; P <0.05), and also the node path length (left, before:18.539 0±0.457 1;after:28.585 8±1.001 4;P <0.05; right, before: 18.650 8±0.438 6; after: 28.853 0±1.652 6;P <0.05). This study was helpful to understand the brain mechanism of rTMS combined with motor training on improvement of motor skill, and comprehend the impact of stroke and brain lesions on brain activities.

Key words： repetitive transcranial magnetic stimulation motor learning phase lag index functional connectivity brain network

Received: 20 December 2017

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R318

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	Articles by authors
	Jin Jingna
	Wang Xin
	Lin Yu
	Zhang Kai
	Li Ying
	Xiang Fang
	Liu Zhipeng
	Yang Xuejun
	Yin Tao

Cite this article:

Jin Jingna,Wang Xin,Lin Yu, et al. The Effects of rTMS Combined with Motor Training on Brain Network in Resting Status[J]. Chinese Journal of Biomedical Engineering, 2018, 37(3): 290-296.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2018.03.005 OR http://cjbme.csbme.org/EN/Y2018/V37/I3/290

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