额颞叶肿瘤患者手术前后大脑网络特性研究

doi:10.3969/j.issn.0258-8021.2018.02.003

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Abstract Brain injury and surgery in brain tumor patients are the most concerned problems in clinical treatments. Based on resting state functional magnetic resonance imaging (fMRI) technology and small world network analysis method, this paper is to study the effect of tumor on the brain's default mode network and sensory motor network in 9 patients with temporal frontal lobe tumor. And the changes of brain function network characteristics were studied by tumor resection. First, the effect of the tumor and resection on the brain's default network and sensory motor network was studied based on the ICA method. Then, the small world network of the patients and normal control group were constructed. The network topology and network parameters were analyzed. We used the betweenness centrality to find out groups of brain functional network core node, and a comparative analysis of changes in patients and normal people at the core node, and preoperative and postoperative core nodes change. Finally, a comparative analysis was conducted on the patients before surgery and after the default mode networks and sensory motor network midbrain region specific changes. The results showed that the nerve activity in default mode network and sensory sports network became lower, suggesting significant damage caused by the tumor in the brain of two modules endogenous network. The small-world attributes(σ=γ/λ)of the patients were significantly reduced (preoperative: 3.591±0.302, postoperative: 3.263±0.174), the cluster coefficients were significantly lower (preoperative: 0.482±0.007, postoperative: 0.454±0.011), and the core nodes shifted to the contralateral side of the tumor. In default network, the resection of the tumor after the operation makes the right brain area activity becomes stronger (preoperative: 0.0125±0.0005, postoperative: 0.0184±0.0010). The activity of the left side of the brain is alleviated. (preoperative: 0.0180±0.0011, postoperative: 0.0122±0.0006). Through the study of the patient's default mode network and sensory motor network, the temporal frontal lobe tumor has a certain effect on the patient's cognitive ability and motor ability, and these abilities could be recovered after surgery.

Key words： resting state small world network core node default mode networks sensorimotor network

Received: 28 March 2017

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R318

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	Articles by authors
	Yang Yuxuan
	Tao Ling
	Qian Zhiyu
	Xue Li
	Yu Yun

Cite this article:

Yang Yuxuan,Tao Ling,Qian Zhiyu, et al. Study on the Brain Network Characteristics before and after the Operation of Frontotemporal Tumor Patients[J]. Chinese Journal of Biomedical Engineering, 2018, 37(2): 146-154.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2018.02.003 OR http://cjbme.csbme.org/EN/Y2018/V37/I2/146

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