提高关节软骨脱细胞支架孔隙率及细胞渗透性方法的研究进展

doi:10.3969/j.issn.0258-8021. 2018. 01.015

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Abstract The regeneration and repair of articular cartilage injury has been a clinical challenge. There has been an increasing focus on developing cartilage tissue engineering due to the limitations of surgical treatment. In cartilage tissue engineering, cartilage matrix is a promising biomaterial for cartilage regeneration given the evidence supporting its chondroinductive character. This natural biomaterial serves as a scaffold which can provide collagen network and biological factors for cartilage tissue regeneration. Decellularization was optimized to remove cells and cell remnants from cartilage effectively. However, the reduced vascularity, limited cell population, and dense extracellular matrix (ECM) inhibit cartilage regeneration. Therefore, most cartilage tissue culture studies focus on improving porosity of the scaffold and promoting cellular migration into central regions. This review focused on recent studies on cartilage ECM scaffold and briefly introduced key ways to obtain high-porosity scaffold that can improve cell infiltration and migration. We summarized from several aspects including decellularization, concentration regulation, oriented freeze-drying, artificial channels and laser micropatterning. By analyzing the principles and advantages of different methods, the importance of pore structure is further emphasized, and the relationship between scaffold performance and regulation methods is clarified.

Key words： decellularization extracellular matrix scaffold tissue engineering

Received: 31 May 2017

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R318

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	Articles by authors
	Zhao Zhongqi
	Wang Xiaokun
	Peng Huimin
	Liang Jiadi
	Wang Xiaojin
	Liu Chang

Cite this article:

Zhao Zhongqi,Wang Xiaokun,Peng Huimin, et al. Research Progress of the Methods Improving Porosity and Cellular Infiltration
in Articular Cartilage Extracellular Matrix Scaffold[J]. Chinese Journal of Biomedical Engineering, 2018, 37(1): 112-118.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021. 2018. 01.015 OR http://cjbme.csbme.org/EN/Y2018/V37/I1/112

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