|
|
Advances in Polymeric Biomaterial Scaffolds for Islet Transplantation |
Liao Shibo1, Huang Shuyu1*, Xi Tingfei2, Wu Min1, Zou Yi1, Li Ling1, Zhu Zhao1 |
1Department of Endocrinology, Xiaogan Hospital Affiliated to Wuhan University of Science and Technology, Xiaogan 432000, Hubei, China; 2Shenzhen Key Laboratory of Human Tissue Regeneration and Repair, Shenzhen Institute, Peking University, Shenzhen 518057, Guangdong, China |
|
|
Abstract The liver may not be an optimal environment for islet transplantation. Problems associated with the hepatic transplantation of islets may preclude the broad application of islet transplantation. Many parts of the body have been tested as alternatives for the intrahepatic transplantation sites. Up to now, none of these sites provided ideal environments for pancreatic islets. Therefore, creating a extrahepatic transplantation site for islets through exploiting biological engineered material scaffolds become a preferred option. In this paper, the research progress on polymeric biomaterial scaffolds for islet transplantation in the last three years were reviewed, including natural polymer scaffolds, synthetic polymer scaffolds, synthetic-natural composite scaffolds, whole organ decellularized scaffolds and three-dimensional bioprinting scaffolds. The prospects was proposed and discussed as well.
|
Received: 04 December 2016
|
|
|
|
|
[1] International Diabetes Federation. Diabetes Atlas [M]. 7th ed. Brussels: International Diabetes Federation, 2015. [2] Kandaswamy R, Stock PG, Skeans MA, et al. OPTN/SRTR 2011 annual data report: pancreas [J]. American Journal of Transplantation, 2013, 13(S1): 47-72. [3] Zinger A, Leibowitz G. Islet transplantation in type 1 diabetes: hype, hope and reality-a clinician's perspective [J]. Diabetes/Metabolism Research and Reviews, 2014, 30(2): 83-87. [4] Phelps EA, Templeman KL, Thulé PM, et al. Engineered VEGF-releasing PEG-MAL hydrogel for pancreatic islet vascularization [J]. Drug Delivery and Translational Research, 2015, 5(2): 125-136. [5] Yang EY, Kronenfeld JP, Stabler CL. Engineering biomimetic materials for islet transplantation [J]. Current Diabetes Reviews, 2015, 11(3): 163-169. [6] Bowers DT, Botchwey EA, Brayman KL. Advances in local drug release and scaffolding design to enhance cell therapy for diabetes [J]. Tissue Engineering Part B: Reviews, 2015, 21(6): 491-503. [7] Barkai U, Rotem A, de Vos P. Survival of encapsulated islets: More than a membrane story [J]. World Journal of Transplantation, 2016, 6(1): 69-90. [8] Farney AC, Sutherland DER, Opara EC. Evolution of islet transplantation for the last 30 years [J]. Pancreas, 2016, 45(1): 8-20. [9] Smink AM, de Haan BJ, Paredes-Juarez GA, et al. Selection of polymers for application in scaffolds applicable for human pancreatic islet transplantation [J]. Biomedical Materials, 2016, 11(3): 035006. [10] McBane JE, Vulesevic B, Padavan DT, et al. Evaluation of a collagen-chitosan hydrogel for potential use as a pro-angiogenic site for islet transplantation [J]. PLoS ONE, 2013, 8(10): e77538. [11] Ellis C, Suuronen E, Yeung T, et al. Bioengineering a highly vascularized matrix for the ectopic transplantation of islets [J]. Islets, 2013, 5(5): 216-225. [12] Ellis CE, Ellis LK, Korbutt RS, et al. Development and characterization of a collagen-based matrix for vascularization and cell delivery [J]. Bio Research Open Access, 2015, 4(1): 188-197. [13] Bhang SH, Jung MJ, Shin JY, et al. Mutual effect of subcutaneously transplanted human adipose-derived stem cells and pancreatic islets within fibrin gel [J]. Biomaterials, 2013, 34(30): 7247-7256. [14] Berman DM, Molano RD, Fotino C, et al. Bioengineering the endocrine pancreas: intraomental islet transplantation within a biologic resorbable scaffold [J]. Diabetes, 2016, 65(5): 1350-1361. [15] Yuan Xiaoqi, Huang Yan, Guo Yibing, et al. Controlling the blood glucose of type 1 diabetes mice by co‐culturing MIN‐6 β cells on 3D scaffold [J]. Pediatric Transplantation, 2015, 19(4): 371-379. [16] Johansson U, Ria M, vall K, et al. Pancreatic islet survival and engraftment is promoted by culture on functionalized spider silk matrices [J]. PLoS ONE, 2015, 10(6): e0130169. [17] Montazeri L, Hojjati-Emami S, Bonakdar S, et al. Improvement of islet engrafts by enhanced angiogenesis and microparticle-mediated oxygenation [J]. Biomaterials, 2016, 89: 157-165. [18] Orr S, Strominger I, Eremenko E, et al. TGF-β affinity-bound to a macroporous alginate scaffold generates local and peripheral immunotolerant responses and improves allocell transplantation [J]. Acta Biomaterialia, 2016, 45: 196-209. [19] Borg DJ, Welzel PB, Grimmer M, et al. Macroporous biohybrid cryogels for co-housing pancreatic islets with mesenchymal stromal cells [J]. Acta Biomaterialia, 2016, 44: 178-187. [20] Phelps EA, Headen DM, Taylor WR, et al. Vasculogenic bio-synthetic hydrogel for enhancement of pancreatic islet engraftment and function in type 1 diabetes [J]. Biomaterials, 2013, 34(19): 4602-4611. [21] Marchioli G, Luca AD, de Koning E, et al. Hybrid polycaprolactone/alginate scaffolds functionalized with VEGF to promote de novo vessel formation for the transplantation of islets of Langerhans [J]. Advanced Healthcare Materials, 2016.5(13): 1606-1616. [22] Smink AM, Hertsig DT, Schwab L, et al. A retrievable, efficacious polymeric scaffold for subcutaneous transplantation of rat pancreatic islets [J]. Annals of Surgery, 2016. [Epub ahead of print] [23] Buitinga M, Truckenmüller R, Engelse MA, et al. Microwell scaffolds for the extrahepatic transplantation of islets of Langerhans [J]. PLoS ONE, 2013, 8(5): e64772. [24] Paredes-Juarez GA, Sahasrabudhe NM, Tjoelker RS, et al. DAMP production by human islets under low oxygen and nutrients in the presence or absence of an immunoisolating-capsule and necrostatin-1 [J]. Scientific Reports, 2015, 5: 14623. [25] Liu JMH, Zhang J, Zhang X, et al. Transforming growth factor-beta 1 delivery from microporous scaffolds decreases inflammation post-implant and enhances function of transplanted islets [J]. Biomaterials, 2016, 80: 11-19. [26] Pedraza E, Brady AC, Fraker CA, et al. Macroporous three-dimensional PDMS scaffolds for extrahepatic islet transplantation [J]. Cell Transplantation, 2013, 22(7): 1123-1135. [27] Schaschkow A, Mura C, Bietiger W, et al. Impact of an autologous oxygenating matrix culture system on rat islet transplantation outcome [J]. Biomaterials, 2015, 52: 180-188. [28] Brady AC, Martino MM, Pedraza E, et al. Proangiogenic hydrogels within macroporous scaffolds enhance islet engraftment in an extrahepatic site [J]. Tissue Engineering Part A, 2013, 19(23-24): 2544-2552. [29] Hosseini-Tabatabaei A, Jalili RB, Khosravi-Maharlooei M, et al. Immunoprotection and functional improvement of allogeneic islets in diabetic mice, using a stable indoleamine 2, 3-dioxygenase producing scaffold [J]. Transplantation, 2015, 99(7): 1341-1348. [30] Hosseini-Tabatabaei A, Jalili RB, Hartwell R, et al. Embedding islet in a liquid scaffold increases islet viability and function [J]. Canadian Journal of Diabetes, 2013, 37(1): 27-35. [31] Mirmalek-Sani SH, Orlando G, McQuilling JP, et al. Porcine pancreas extracellular matrix as a platform for endocrine pancreas bioengineering [J]. Biomaterials, 2013, 34(22): 5488-5495. [32] Goh SK, Bertera S, Olsen P, et al. Perfusion-decellularized pancreas as a natural 3D scaffold for pancreatic tissue and whole organ engineering [J]. Biomaterials, 2013, 34(28): 6760-6772. [33] Xu Tianxin, Zhu Mingyan, Guo Yibing, et al. Three-dimensional culture of mouse pancreatic islet on a liver-derived perfusion-decellularized bioscaffold for potential clinical application[J]. Journal of Biomaterials Applications, 2015, 30(4): 379-387. [34] 朱沙俊, 徐天鑫, 王雷, 等. 小鼠胰岛与肝脏脱细胞支架三维共培养的实验研究[J]. 南京医科大学学报:自然科学版, 2015, 35(12): 1685-1690. [35] Ozbolat IT. Scaffold-based or scaffold-free bioprinting: competing or complementing approaches? [J]. Journal of Nanotechnology in Engineering and Medicine, 2015, 6(2): 024701. [36] Ozbolat IT, Peng W, Ozbolat V. Application areas of 3D bioprinting [J]. Drug Discovery Today, 2016, 21(8): 1257-1271. [37] Gudupati H, Dey M, Ozbolat I. A comprehensive review on droplet-based bioprinting: past, present and future [J]. Biomaterials, 2016.102: 20-42. [38] Wszola M, Idaszek J, Berman A, et al. Bionic pancreas and bionic organs-how far we are from the success [J]. MEDtube Science, 2015, 3(3): 25-27. [39] Marchioli G, Van Gurp L, Van Krieken PP, et al. Fabrication of three-dimensional bioplotted hydrogel scaffolds for islets of Langerhans transplantation [J]. Biofabrication, 2015, 7(2): 025009. [40] Hwang PTJ, Shah DK, Garcia JA, et al. Progress and challenges of the bioartificial pancreas[J]. Nano Convergence, 2016, 3(1): 28. |
[1] |
Shi Jie, Tang Di Gao, Jingchen, Kong Deling, Wang Shufang. The Effect of Macrophages on the Post-Implantation Reaction of Biomaterials and Tissue Regeneration[J]. Chinese Journal of Biomedical Engineering, 2017, 36(6): 749-754. |
[2] |
Ren Hao, Li Rongke, Wang Ren. Progress and Challenges of Bioresorbable Vascular Scaffolds[J]. Chinese Journal of Biomedical Engineering, 2017, 36(3): 354-359. |
|
|
|
|