基于光学相干断层扫描成像的眼部三维前房角

doi:10.3969/j.issn.0258-8021.2012.06.005

Abstract
Figure/Table
References (0)
Related Citation (5)

Download: PDF (616 KB) HTML (1 KB)
Export: BibTeX | EndNote (RIS)

Abstract In this article, an automatic method for measuring 3-dimensional (3D) anterior chamber eye angle opening distance (AOD) with Fourier-domain optical coherence tomography (OCT) was proposed. A special 3D “Angle Arc” scan pattern composed of 25 cross-sectional OCT image frames was designed. The initial boundaries of the anterior and posterior cornea and anterior iris were located in all the frames and then refined. Human input was needed to identify Schwalbe's line (SL) in 3 key frames of each 3D dataset. Next, the computer algorithm was employed to estimate SL locations in the rest 22 frames according to a mapping method. Last, the angle opening distance based on the SL (AOD-SL) was calculated for all the frames. Result showed that the computer algorithm provided a robust and accurate method to measure 3D AOD-SL. The precise angle boundary detection was 96.06% in image frames, and accuracy of the AOD-SL measurement in the key frames was 95.11% by using the automated AOD-SL measurements.The automated AOD-SL measurements agreed well with the human measurements with computer calipers.

Key words： optical coherence tomography anterior chamber angle imaging image segmentation angle opening distance 3-dimensional anterior chamber angle scan pattern

	Service

	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	WU Wei¹DUAN Hui Long^1*LI Yan^2JIANG Chun Hui^3QIN Bing^3HUANG David^2

Cite this article:

WU Wei¹DUAN Hui Long^1*LI Yan^2JIANG Chun Hui^3QIN Bing^3HUANG David^2
. Anterior Chamber Angle Measurements with High Resolution Fourier-Domain Optical Coherence Tomography[J]. journal1, 2012, 31(6): 831-838.

URL:

http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2012.06.005 OR http://cjbme.csbme.org/EN/Y2012/V31/I6/831

［1］Bouma BE, Tearney GJ. Handbook of OCT［M］. New York: MarcelDekker, Inc., 2002.
［2］Huang D, Swanson EA, Lin CP, et al. Optical coherence tomography［J］. Science, 1991,254(5035):1178-1181.
［3］Choma M, Sarunic M, Yang C, et al. Sensitivity advantage of swept source and Fourier domain optical coherence tomography［J］. Opt Express, 2003,11(18):2183-2189.［4］Leitgeb R, Hitzenberger C, Fercher A. Performance of fourier domain vs. Time domain optical coherence tomography［J］. Opt Express, 2003,11(8):889-894.
［5］Grehn F, Stamper R. Glaucoma ［M］// Sharma T, Low S, Foster PJ, eds.. The Classification of Primary AngleClosure Glaucoma. Heidelberg: Springer, 2009:41-42. 
［6］Quigley HA, Broman AT. The number of people with glaucoma worldwide in 2010 and 2020［J］. Br J Ophthalmol, 2006,90(3):262-267.
［7］Razzaq L, Emmanouilidisvan der Spek K, Luyten GPM, et al. Anterior segment imaging for iris melanocytic tumors［J］. Eur J Ophthalmol, 2011,21(5):608-614.
［8］Ishikawa H, Inazumi K, Liebmann JM, et al. Inadvertent corneal indentation can cause artifactitious widening of the iridocorneal angle on ultrasound biomicroscopy［J］. Ophthalmic Surg Lasers, 2000,31(4):342-345.
［9］Console JW, Sakata LM, Aung T, et al. Quantitative analysis of anterior segment optical coherence tomography images: The zhongshan angle assessment program［J］. Br J Ophthalmol, 2008,92(12):1612-1616.
［10］Pavlin CJ, Harasiewicz K, Foster FS. Ultrasound biomicroscopy of anterior segment structures in normal and glaucomatous eyes［J］. Am J Ophthalmol, 1992,113(4):381-389.
［11］刘家崎, 李凤鸣. 实用眼科学［M］. (第二版). 北京: 人民卫生出版社, 1984:414-420.
［12］Huang D. RTVue Fourierdomain optical coherence tomography primer series: Vol ii cornea & anterior segment ［M］// Memarzadeh F, Binder PS, Ramos S, eds, Imaging the Anterior Chamber Angle. Fremont: Optovue, 2009:54. 
［13］Qin B, Francis BA, Li Y, et al. Anterior chamber angle measurements using schwalbes line with high resolution Fourierdomain optical coherence tomography［J］. J Glaucoma, 23 Jul, 2012 ［Epub ahead of print］. 
［14］Huang D, Duker J, Fujimoto J, et al. Imaging the eye from front to back with the RTVue optical coherence tomography［M］ // Memarzadeh F, Mahdaviani S, Li Y，eds. Interpretation of Angle Images. Thorofare:SLACK Inc.,2010:47-51. 
［15］Cheung CY, Zheng C, Ho CL, et al. Novel anteriorchamber angle measurements by highdefinition optical coherence tomography using the schwalbe line as the landmark［J］. Br J Ophthalmol, 2011,95(7):955-959.
［16］Wu W, Li Y, Huang D, et al. A compound segmentation algorithm for anterior chamber angle in OCT image［C］ // Ding Yongsheng, Peng Yonghong, Shi Riyi, eds. The 4th International Conference on BioMedical Engineering and Informatics. Shanghai: IEEE,2011:13-16.
［17］Leung CKS, Li HT, Weinreb RN, et al. Anterior chamber angle measurement with anterior segment optical coherence tomography: A comparison between slit lamp OCT and visante OCT［J］. Invest Ophthalmol Vis Sci, 2008,49(8):3469-3474.
［18］Cleveland WS, Grosse E. Computational methods for local regression［J］. Statistics and Computing, 1991,1(1):47-62.
［19］Leung CKS, Weinreb RN. Anterior chamber angle imaging with optical coherence tomography［J］. Eye, 2011,25(3):261-267.