闭环式电刺激抑制痫样棘波发放的机制研究

doi:10.3969/j.issn.0258-8021.2016.01.010

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Abstract Deep brain stimulation (DBS) is an attractive alternative strategy to surgical excision of the seizure focuses for epilepsy treatments in clinic. However, epilepsy can be generated by various mechanisms, and this highlights a need in designing pertinent DBS patterns with customized parameters for the effective therapy. In the present study, high-frequency stimulation (HFS) pulse trains with short durations were used against the epileptic form activity induced by picrotoxin, an antagonist of GABAergic receptors, in the hippocampal CA1 region of anaesthetized rats. In a closedloop manner, the HFS train was applied during each period of epileptic form bursts to the afferent axon tracts (i.e. the Schaffer collaterals) of CA1 region. The experiment results from 9 rats show that HFS trains with a frequency over 100 Hz and duration of 0.3 s during bursts suppressed 60-70% of the spikes in the bursts. Meanwhile, during the periods of HFS against bursts, the neurons of CA1 region failed to respond to the excitation of antidromic stimulation applied to the efferent axon tracts (i.e. the alveus), indicating that the neurons temporarily lost their ability to generate action potentials. Therefore, presumably, the mechanism of spike suppression by HFS might be a depolarization block generated within neuronal membranes. The finding of the study provides important insight into the development of novel closedloop stimulation patterns of DBS in treating epilepsy.

Key words： deep brain stimulation closed-loop epilepsy picrotoxin depolarization block

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	Articles by authors
	Cao Jiayue Feng Zhouyan^*Guo Zheshan Hu Zhenhua Hu Na

Cite this article:

Cao Jiayue Feng Zhouyan^*Guo Zheshan Hu Zhenhua Hu Na. Mechanism of Suppression of Epileptiform Burst by Closed-Loop Electrical Stimulation[J]. journal1, 2016, 35(1): 79-87.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2016.01.010 OR http://cjbme.csbme.org/EN/Y2016/V35/I1/79

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