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| Research on Capture Efficiency of Targeting Magnetic Drug Target Delivery Based on Non-Newton Fluid Multiphase Flow |
1 School of Mechanical Engineering Shanghai Jiaotong University, Shanghai 200240, China
2 Shanghai Six Hospital, Shanghai 200240, China |
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Abstract In order to analyze the influence of magnetic parameters on capture efficiency, a two phase CassonNewton model was developed to describe magnetic drug flowage in blood based on blood and rectangular magnet properties. The motion of magnetic nanoparticles under magnetic force and fluid force in blood vessel was analyzed, theoretic formulation of blood vessel 3D capture efficiency and further propose optimization model for capture drug volume was obtained to improve drug efficacy. Blood velocity and capture efficiency of Casson-Newton model, Newton model and Casson model were simulated by Matlab and compared to reveal the variation of capture drug volume, and the effects of particle radius, magnetic material radius ratio, magnetic field strength, distance between magnet and blood vessel, vessel radius, and other parameters on capture efficiency. According to the analysis results, the Non-Newton multiphase model performed system property better, the capture efficiency of Casson-Newton model was 4% higher than the two other models, and the capture drug volume reached maximum when magnetic materials radius ratio was 0.75 .
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