|
|
|
| search of Structural Connectivity of Cognitive Control Network in Childhood Absence Epilepsy Based on Diffusion Tensor Imaging |
1(Key laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China
2 Department of Neurology, West China Hospital of Sichuan University, Chengdu 610041, China
3 Department of Neurology, The Affiliated Hospital of Hainan Medical College, Haikou, 570102 China |
|
|
|
|
Abstract It was reported that functional connectivity in cognitive control network (CCN) was altered in patients with childhood absence epilepsy. In order to explore the structural connectivity in CCN, nine patients with childhood absence epilepsy and 12 healthy controls were recruited. The fiber bundles among regions of CCN were tracked by diffusion tensor imaging (DTI) in each subject. The parameters (including count, length, weight, mean of fractional anisotropic (FA) and mean diffusivity (MD)) of the each fiber bundle were assessed between the two groups using 2-sample Ttest. The significantly decreased FA and increased MD in main fiber bundles were detected in the patient group (Ps<0.05, Bonferroni corrected). Furthermore, the mean FA value in the fiber bundles between left prefrontal cortex and thalamus was negatively related to the epilepsy duration (P=0.011). These findings might provide potential structural evidence for the altered functional connectivity in CCN in absence epilepsy. The results implied that the abnormalities of structural connections might be one of the important factors that result in cognitive control dysfunction in the patients with childhood absence epilepsy.
|
|
|
|
|
|
［1］Egner T, Hirsch J. The neural correlates and functional integration of cognitive control in a Stroop task ［J］. NeuroImage, 2005, 24(2): 539-547.
［2］尧德中, 罗程, 雷旭, 等. 脑成像与脑连接 ［J］. 中国生物医学工程学报, 2011, 30(1): 6-10.
［3］Niendam TA, Laird AR, Ray KL, et al. Metaanalytic evidence for a superordinate cognitive control network subserving diverse executive functions ［J］. Cognitive, Affective, & Behavioral Neuroscience, 2012: 1-28.
［4］Aron AR, Behrens TE, Smith S, et al. Triangulating a cognitive control network using diffusionweighted magnetic resonance imaging (MRI) and functional MRI ［J］. The Journal of Neuroscience, 2007, 27(14): 3743-3752.
［5］Harvey PO, Fossati P, Pochon JB, et al. Cognitive control and brain resources in major depression: An fMRI study using the nback task ［J］. NeuroImage, 2005, 26(3): 860-869.
［6］Caplan R, Siddarth P, Stahl L, et al. Childhood absence epilepsy: behavioral, cognitive, and linguistic comorbidities ［J］. Epilepsia, 2008, 49(11): 1838-1846.
［7］郑玲, 张志强, 王正阁, 等. 儿童期失神癫痫静息态脑网络改变的脑电图联合功能磁共振成像研究 ［J］. 中国现代神经疾病杂志, 2012, 12(5): 558-562.
［8］Yang Tianhua, Luo Cheng, Li Qifu, et al. Altered RestingState Connectivity During Interictal Generalized SpikeWave Discharges in DrugNaive Childhood Absence Epilepsy ［J］. Hum Brain Mapp, 2012, 3(19): 1-7.
［9］张浩, 钱志余, 卢光明, 等. 同步脑电功能磁共振成像技术对儿童失神性癫痫的研究 ［J］. 生物物理学报, 2011, 27(2): 167-174.
［10］Gotman J, Grova C, Bagshaw A, et al. Generalized epileptic discharges show thalamocortical activation and suspension of the default state of the brain ［J］. Proceedings of the National Academy of Sciences of the United States of America, 2005, 102(42): 15236-15240.
［11］Ciccarelli O, Catani M, JohansenBerg H, et al. Diffusionbased tractography in neurological disorders: concepts, applications, and future developments ［J］. The Lancet Neurology, 2008, 7(8): 715-727.
［12］Liao Wei, Zhang Zhiqiang, Pan Zhengyong, et al. Default mode network abnormalities in mesial temporal lobe epilepsy: A study combining fMRI and DTI ［J］. Human Brain Mapping, 2011, 32(6): 883-895.
［13］Chao Yiping, Chen Jyhhorng, Cho Kuanhuang, et al. A multiple streamline approach to high angular resolution diffusion tractography ［J］. Medical Engineering & Physics, 2008, 30(8): 989-996.
［14］Hagmann P, Cammoun L, Gigandet X, et al. Mapping the structural core of human cerebral cortex ［J］. PLoS Biology, 2008, 6(7): 1479-1493.
［15］Hagmann P, Sporns O, Madan N, et al. White matter maturation reshapes structural connectivity in the late developing human brain ［J］. Proceedings of the National Academy of Sciences of the United States of America, 2010, 107(44): 19067-19072.
［16］Holroyd CB, Nieuwenhuis S, Yeung N, et al. Dorsal anterior cingulate cortex shows fMRI response to internal and external error signals ［J］. Nature Neuroscience, 2004, 7(5): 497-498.
［17］Miller EK. The prefrontal cortex and cognitive control ［J］. Nature Reviews Neuroscience, 2000, 1(1): 59-66.
［18］Nachev P, Kennard C,Husain M. Functional role of the supplementary and presupplementary motor areas ［J］. Nature Reviews Neuroscience, 2008, 9(11): 856-869.
［19］Behrens T, JohansenBerg H, Woolrich M, et al. Noninvasive mapping of connections between human thalamus and cortex using diffusion imaging ［J］. Nature Neuroscience, 2003, 6(7): 750-757.
［20］Crunelli V, Leresche N. Childhood absence epilepsy: genes, channels, neurons and networks ［J］. Nature Reviews Neuroscience, 2002, 3(5): 371-382.
［21］Killory BD, Bai X, Negishi M, et al. Impaired attention and network connectivity in childhood absence epilepsy ［J］. NeuroImage, 2011, 56(4): 2209-2217.
［22］Kaiser M, Hilgetag CC. Nonoptimal component placement, but short processing paths, due to longdistance projections in neural systems ［J］. PLoS Computational Biology, 2006, 2(7): 805-815.
［23］Blumenfeld H, Taylor J. Why do seizures cause loss of consciousness? ［J］. The Neuroscientist, 2003, 9(5): 301-310.
［24］Chahboune H, Mishra A, DeSalvo M, et al. DTI abnormalities in anterior corpus callosum of rats with spikewave epilepsy ［J］. NeuroImage, 2009, 47(2): 459-466.
［25］Leung HC, Skudlarski P, Gatenby JC, et al. An eventrelated functional MRI study of the Stroop color word interference task ［J］. Cerebral Cortex, 2000, 10(6): 552-560.
［26］Behrens T, Berg HJ, Jbabdi S, et al. Probabilistic diffusion tractography with multiple fibre orientations: What can we gain? ［J］. NeuroImage, 2007, 34(1): 144-155.
［27］Loring DW, Meador KJ. Cognitive side effects of antiepileptic drugs in children ［J］. Neurology, 2004, 62(6): 872-877.
［28］Mula M, Trimble MR. Antiepileptic druginduced cognitive adverse effects: potential mechanisms and contributing factors ［J］. CNS drugs, 2009, 23(2): 121-137. |
|
|
|
