search of Structural Connectivity of Cognitive Control Network in Childhood Absence Epilepsy Based on Diffusion Tensor Imaging
1(Key laboratory for Neuroinformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China
2 Department of Neurology, West China Hospital of Sichuan University, Chengdu 610041, China
3 Department of Neurology, The Affiliated Hospital of Hainan Medical College, Haikou, 570102 China
Abstract It was reported that functional connectivity in cognitive control network (CCN) was altered in patients with childhood absence epilepsy. In order to explore the structural connectivity in CCN, nine patients with childhood absence epilepsy and 12 healthy controls were recruited. The fiber bundles among regions of CCN were tracked by diffusion tensor imaging (DTI) in each subject. The parameters (including count, length, weight, mean of fractional anisotropic (FA) and mean diffusivity (MD)) of the each fiber bundle were assessed between the two groups using 2-sample Ttest. The significantly decreased FA and increased MD in main fiber bundles were detected in the patient group (Ps<0.05, Bonferroni corrected). Furthermore, the mean FA value in the fiber bundles between left prefrontal cortex and thalamus was negatively related to the epilepsy duration (P=0.011). These findings might provide potential structural evidence for the altered functional connectivity in CCN in absence epilepsy. The results implied that the abnormalities of structural connections might be one of the important factors that result in cognitive control dysfunction in the patients with childhood absence epilepsy.
XUE Kai Qing1 LUO Cheng1* TIAN Yin1 YANG Tian Hua2LI Qi Fu2,3ZHOU Dong2YAO De Zhong. search of Structural Connectivity of Cognitive Control Network in Childhood Absence Epilepsy Based on Diffusion Tensor Imaging[J]. journal1, 2013, 32(4): 426-432.
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