|
|
Experimental Study of Dielectric Properties on Human Lung Tissue |
1 Institute of Electrical Engineering and Automation, Tianjin University, Tianjin 300072, China
2 Department of Radiotherapy, General Hospital of Tianjin Medical University, Tianjin 300052, China |
|
|
Abstract This study is aim to investigate the differences of dielectric properties between lung cancer tissue and the normal tissue in vitro and establish the dielectric parameter frequency spectrum of human lung tissue which provide the basic theory and reference data for medical research and clinical diagnosis of lung cancer. Two main categories of tissues were considered as specimens: the central part of the tumor and the normal tissue around the tumor. After operation, specimens was put into test chamber in which the temperature and humidity were controlled at expected values. Then the measurement of specimens’ dielectric properties was performed at frequency from 100 Hz to 100 MHz using 4294A impedance analyzer of Agilent Company. Finally the two categories of tissues’ characteristic parameters were extracted by using the least square curve fitting method based on Cole-Cole model. The relative permittivity of lung cancer tissue was 3~5 times larger than that of the normal tissue. The conductivity of lung cancer tissue was 1.6~3.3 times larger than that of the normal tissue. Impedance spectroscopy of lung cancer tissue moved apparently to low impedance direction. Among the characteristic parameters (R0,R∞,α,τandfc), the difference of low frequency resistance (R0) between the two categories of tissues was statistically significant (P<0.05). The differences of dielectric properties and low frequency resistance between lung cancer tissue and the normal tissue are significant, which provide basic data for human lung tissue’s dielectric properties research and EIT measurement.
|
|
|
|
|
[1]Jemal A, Bray F, Center MM, et al. Global cancer statistics [J]. CA Cancer J Clin, 2011, 61(2): 69-90.
[2]董秀珍. 生物电阻抗成像研究的现状与挑战 [J]. 中国生物医学工程学报, 2008, 27(3): 641-649.
[3]Gabriel C, Gabriel S, Corthout E. The dielectric properties of biological tissues: I. Literature survey [J]. Phys Med Biol, 1996, 41: 2231-2249.
[4]Gabriel S, Lau RW, Gabriel C. The dielectric properties of biological tissues: II. Measurements in the frequency range 10 Hz to 20 GHz [J]. Phys Med Biol, 1996, 41(11): 2251-2269.
[5]Gabriel S, Lau RW, Gabriel C. The dielectric properties of biological tissues: III. Parametric models for the dielectric spectrum of tissues [J]. Phys Med Biol, 1996, 41: 2271-2293.
[6]付峰,臧益民,董秀珍,等. 部分离体动物组织复阻抗频率特性(100 Hz~10 MHz)测量系统及初步测量结果 [J]. 第四军医大学学报, 1999, 20(3): 220-222.
[7]林新. 生物组织组抗频谱测量技术及特性的基础研究 [D]. 西安: 第四军医大学, 2005.
[8]蔡占秀,史学涛,王廷,等. 正常乳腺脂肪与腺体组织介电特性研究 [J]. 医疗卫生装备, 2012, 33(5): 1-3.
[9]Taehong K, Junhurt O, Bongseok K, et al. A study of dielectric properties of fatty, malignant and fibroglandular tissues in female human breast. [C]//Electromagnetic Compatibility and 19th International Zurich Symposium on Electromagnetic Compatibility, 2008. APEMC 2008. AsiaPacific Symposium on 19-23 May 2008: 216-219.
[10]Xiao Funian, Otto K, Camarillo IG. The dielectric properties of electroporated human breast cancer cells. [C]// IEEE 10th International Conference on the
|
|
|
|