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| Brain Electrical Source Analysis of EventRelated Potentials in Depressive Disorder |
1 College of Mechatronics and Control Engineering, Shenzhen University, Shenzhen, 518060, China
2 Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China
3 College of Precision Instrument and Optoelectronics Engineering, Tianjin University, Tianjin, 300072, China |
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Abstract Using visual threestimulus oddball paradigm, activities of cortical current sources elicited by target and distractor stimuli were investigated in depressive patients. The 64-channel EEG signals were recorded in healthy subjects and depressed patients during the task. A regional source model with constraints of spatial coordinates from fMRI BOLD clusters was applied to eventrelated potentials (ERPs) data in the target and distractor conditions. The reconstructed source activities were sent to unpaired t-test and permutation test, statistical results indicated source activities in the right insular and right precentral sulcus in the late phase of P300 show significant difference between patients and healthy controls in the target condition, and scalp voltage maps projected by the current flow direction of corresponding regional sources in patients show abnormal negative potential over the right prefrontal scalp area. It was also found that source activity in the left precentral sulcus in the late phase of P300 showed significant difference at a trend level (P=0.087) in the distractor condition. Scalp voltage map showed abnormal nearzero potential over the left prefrontal area.
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［1］Donchin E, Coles MG. Is the P300 component a manifestation of context updating?［J］ Behav Brain Sci, 1998, 11:357-374.
［2］Kok A. On the utility of P3 amplitude as a measure of processing capacity［J］. Psychophysiology, 2001, 38:557-577.
［3］Friedman D, Cycowicz YM, Gaeta H. The novelty P3: an eventrelated brain potential (ERP) sign of the brain’s evaluation of novelty［J］. Neurosci Biobehav Rev, 2001, 25:355-373.
［4］Ebmeier K, Rose E, Steele D. Cognitive Impairment and fMRI in Major Depression［J］. Neurotoxicity Research, 2006, 10(2): 87-92
［5］Bruder GE, Kayser J, Tenke J, et al. Cognitive ERPs in depressive and anxiety disorders during tonal and phonetic oddball tasks［J］. Clinical Electroencephalography, 2002, 33(3): 119-124.
［6］Bledowski C, Prvulovic D, Hoechstetter K, et al. Localizing P300 generators in visual target and distractor processing: a combined eventrelated potential and functional magnetic resonance imaging study ［J］. Journal of Neuroscience, 2004, 24(42): 9353-9360.
［7］Huettel SA, Guzeldere G, McCarthyG。 Dissociating the neural mechanisms of visual attention in change detection using functional MRI ［J］. J Cogn Neurosci, 2001，13:1006-1018.
［8］Shulman GL, McAvoy MP, Cowan MC, et al. Quantitative analysis of attention and detection signals during visual search ［J］. J Neurophysiol, 2003, 90:3384-3397.
［9］Taylor KS, Seminowicz DA, Davis KD. Two systems of resting state connectivity between the insula and cingulate cortex［J］. Hum Brain Mapp, 2009, 30 (9): 2731-2745.
［10］Eckert MA, Menon V, Walczak A, et al. At the heart of the ventral attention system: the right anterior insula［J］. Hum Brain Mapp, 2009, 30(8):2530-2541.
［11］Cabeza R, Nyberg L. Neural bases of learning and memory: functional neuroimaging evidence［J］. Curr Opin Neurol, 2009,13: 415-421.
［12］Linden DEJ, Bittner RA, Muckli L, et al. Cortical capacity constraints for visual working memory: dissociation of fMRI load effects in a frontoparietal network［J］. NeuroImage, 2003, 20: 1518-1530. |
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