Abstract In this paper, an electrochemical detection method for simultaneous detection of paracetamol (PA) and ascorbic acid (AA) concentrations was investigated. Experimental data were collected through a three-electrode electrochemical workstation, and PBs/cMWCNTs/GCE electrochemical sensors were prepared using cyclic voltammetry (CV), which resulted in basic separation of the peak potentials of PA and AA. Differential pulse voltammetry (DPV) and chronoamperometry (CA) were used to conduct electrochemical detection of PA and AA mixed solutions with different concentrations, and typical electrochemical features and image features of the detection curves were extracted. Then, the improved particle swarm optimization-backtracking search algorithm (PSO-BSA) network was used to decouple the experimental data and construct an accurate prediction model for the concentration of PA and AA in the mixed sample. Finally, the simultaneous detection of PA and AA dual-chemical drugs was achieved. The R-Square (R2) of the prediction results reached 0.995, the root mean square error (RMSE) reached 0.137 mM, and the mean absolute error (MAE) reached 0.124 mM. The method proposed in this study has the advantages of easy operation, satisfactory goodness of fit, and high cost-effectiveness, which is conducive in achieving synergistic detection results of PA and AA mixed drugs and achieving accurate analysis of the components of a certain drug sample.
Guo Boyu,Bao Hanyang,Rao Zhikang, et al. Accurate Prediction of Paracetamol and Ascorbic Acid Mixed Solutions Based onPSO-BSA Heuristic Algorithm[J]. Chinese Journal of Biomedical Engineering, 2024, 43(6): 702-711.
[1] Chidiac AS, Buckley NA, Noghrehchi F, et al. Paracetamol (acetaminophen) overdose and hepatotoxicity: Mechanism, treatment, prevention measures, and estimates of burden of disease [J]. Expert Opin Drug Metab Toxicol, 2023, 19(5): 297-317.
[2] Wang Dandan, Yin Zequn, Han Lan, et al. Ascorbic acid inhibits transcriptional activities of lxrα to ameliorate lipid metabolism disorder [J]. Journal of Functional Foods, 2022, 88: 104901.
[3] Montalto M, Porceddu E, Pero E, et al. Scurvy: a disease not to be forgotten[J]. Nutr Clin Pract, 2021, 36(5): 1063-1067.
[4] Deng, Peihong, Feng Jinxia, Xiao Jingyun, et al. Application of a simple and sensitive electrochemical sensor in simultaneous determination of paracetamol and ascorbic acid [J]. Journal of the Electrochemical Society, 2021, 168(9): 096501.
[5] Anitta S, Sekar C. Voltammetric determination of paracetamol and ciprofloxacin in the presence of vitamin C using cuttlefish bone-derived hydroxyapatite sub-microparticles as electrode material [J]. Results in Chemistry, 2023, 5: 100816.
[6] Masihpour N, Hassaninejad-Darzi SK, Sarvary A. Nickel-cobalt salen organometallic complexes encapsulated in mesoporous naa nanozeolite for electrocatalytic quantification of ascorbic acid and paracetamol [J]. J Inorg Organomet Polym Mater, 2023: 1-20.
[7] Van Der Horst C, Silwana B, Gil E, et al. Simultaneous detection of paracetamol, ascorbic acid, and caffeine using a bismuth-silver nanosensor [J]. Electroanalysis, 2020, 32(12): 3098-3107.
[8] Thomas OE, Akin-Taylor A, Oyetunde YS, et al. Spectroscopic study of drug-drug interactions: Influence of two over-the-counter drugs on the albumin binding affinities of carbamazepine and its major metabolite [J]. Future Journal of Pharmaceutical Sciences, 2023, 9(1): 90.
[9] 施高凡, 林祥德, 柳华杰, 等. 层层自组装薄膜改性的电化学传感器应用 [J]. 中国生物医学工程学报, 2023, 42(3): 370-384.
[10] Eskiköy Bayraktepe D, Yazan Z. Application of single‐use electrode based on nano‐clay and mwcnt for simultaneous determination of acetaminophen, ascorbic acid and acetylsalicylic acid in pharmaceutical dosage [J]. Electroanalysis, 2020, 32(6): 1263-1272.
[11] Kaveh M, Mesgari MS. Application of meta-heuristic algorithms for training neural networks and deep learning architectures: A comprehensive review [J]. Neural Process Lett, 2022, 55(4): 4519-4622.
[12] 常盼春, 杨济民, 杨娟, 等. 基于粒子群算法与反向传播神经网络的呼吸运动预测研究 [J]. 中国生物医学工程学报, 2018, 37(6): 714-719.
[13] 吴玉文, 牛智越, 韩倩倩. 基于启发式搜索算法的无人机航迹快速规划 [J]. 科学技术与工程, 2020, 20(20): 8394-8399.
[14] Nama S, Saha AK, Chakraborty S, et al. Boosting particle swarm optimization by backtracking search algorithm for optimization problems [J]. Swarm and Evolutionary Computation, 2023, 79: 101304.
[15] Anilkumar P, Pamu D, Tiwari T. Optimization using backtracking search algorithm for the design of magnetron anode block and pill-box rf window [J]. IEEE Journal on Multiscale and Multiphysics Computational Techniques, 2023, 8: 314-321.
[16] Zhang Di, Lin Zitao, Xuan Lilei, et al. Rapid determination of geographical authenticity and pungency intensity of the red sichuan pepper (zanthoxylum bungeanum) using differential pulse voltammetry and machine learning algorithms [J]. Food Chem, 2024, 439: 137978.
[17] Chen Rongfa, Ye Chengcong, Li Fangfang, et al. Filtered cathodic vacuum arc deposition of tetrahedral amorphous carbon thin films on surgical blades and its corrosion resistance in phosphate buffer solution (pbs) at pH 7.4 [J]. International Journal of Electrochemical Science, 2023, 18(6): 100135.
[18] Ren Shufang, Cui Wangyong, Liu Ying, et al. Molecularly imprinted sensor based on 1t/2h mos2 and mwcnts for voltammetric detection of acetaminophen [J]. Sensors and Actuators A: Physical, 2022, 345: 113772.
[19] Ortiz-Aguayo D, Bonet-San-Emeterio M, Del Valle M. Simultaneous voltammetric determination of acetaminophen, ascorbic acid and uric acid by use of integrated array of screen-printed electrodes and chemometric tools [J]. Sensors, 2019, 19(15): 3286.
[20] Vazan M, Tashkhourian J, Haghighi B. A novel electrochemical sensor based on moo3 nanobelt-graphene oxide composite for the simultaneous determination of paracetamol and 4-aminophenol [J]. Diamond and Related Materials, 2023, 140: 110549.
[21] He Yapeng, Wang Xue, Huang Weimin, et al. Hydrophobic networked PBO(2) electrode for electrochemical oxidation of paracetamol drug and degradation mechanism kinetics [J]. Chemosphere, 2018, 193: 89-99.
[22] Ansah IB, Lee W-C, Mun C, et al. In situ electrochemical surface modification of au electrodes for simultaneous label-free sers detection of ascorbic acid, dopamine and uric acid [J]. Sensors and Actuators B: Chemical, 2022, 353: 131196.
[23] Clares P, Pérez-Ràfols C, Serrano N, et al. Voltammetric determination of active pharmaceutical ingredients using screen-printed electrodes [J]. Chemosensors, 2022, 10(3): 95-108.
[24] De Oliveira Filho JI, Faleiros MC, Ferreira DC, et al. Empowering electrochemical biosensors with Ai: overcoming interference for precise dopamine detection in complex samples [J]. Advanced Intelligent Systems, 2023, 5(10): 2300227.
