基于光遗传学技术的脑机接口研究进展

doi:10.3969/j.issn.0258-8021.2024.02.008

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Abstract As bidirectional communication systems between human brains and external devices, brain-computer interfaces (BCIs) have been widely employed in brain function enhancement, human-computer interaction and nerve rehabilitation. BCIs based on optogenetics remedy for the deficits of electrode stimulation in biological compatibility, stimulation accuracy and cell type specificity, thus becoming a hotspot in the research of neural engineering. In this review, we first described the application of optogenetic interfaces in animal experiments such as closed-loop control of brain activity, virtual sensation feedback, or brain-brain information channel. Subsequently, frontiers of novel integrated and miniaturized optogenetic interfaces were summarized. At last, we recapitulated the current challenges of optogenetic brain-computer interfaces, along with the prospects of optogenetic interface in multimodal brain activity monitoring and brain-computer intelligence.

Key words： neural engineering brain-computer interface optogenetics closed-loop feedback

Received: 23 March 2023

PACS:

R318

Corresponding Authors: ^* E-mail: lixiangning@hainanu.edu.cn

About author:: ^#Senior member, Chinese Society of Biomedical Engineering

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	Meng Zhaoyang
	Pu Jiangbo
	Li Xiangning

Cite this article:

Meng Zhaoyang,Pu Jiangbo,Li Xiangning. Research Progress of Optogenetic Brain-Computer Interface[J]. Chinese Journal of Biomedical Engineering, 2024, 43(2): 204-213.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2024.02.008 OR http://cjbme.csbme.org/EN/Y2024/V43/I2/204

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