脊髓电刺激治疗帕金森病步态冻结症状的电生理学研究进展

doi:10.3969/j.issn.0258-8021.2023.05.010

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Abstract Freezing of gait (FoG) is a severe symptom of Parkinson's disease (PD), which has a high incidence rate and seriously affects the quality of life of patients. Currently, there are no ideal methods for the treatment of FoG. Spinal cord stimulation (SCS) is a therapeutic way of electrical stimulation of the spinal cord, which has the advantage of causing less surgical trauma. From the perspective of SCS technology to improve the electrophysiological treatment mechanism of FoG, this paper first introduced the abnormal anatomical mechanism of FoG, followed by reviewing the research progress of abnormal electrophysiology of FoG from the level of cortex and deep brain, and then discussed the electrophysiological mechanism of SCS regulation of FoG from the clinical and animal models. Finally, we summarized the limitations and deficiencies of the current SCS and explored application prospects, possible improvement directions, and future development trends of SCS in the treatment of FoG.

Key words： freezing of gait spinal cord stimulation electrophysiological mechanism Parkinson′s disease

Received: 08 August 2022

PACS:

R318

Corresponding Authors: ^*E-mail: weijing@ccmu.edu.cn

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	Li Ziyun
	Li Jiping
	Wei Jing

Cite this article:

Li Ziyun,Li Jiping,Wei Jing. Advances in Electrophysiological Research of Spinal Cord Stimulation on
Freezing of Gaitin Parkinson′s Disease[J]. Chinese Journal of Biomedical Engineering, 2023, 42(5): 603-609.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2023.05.010 OR http://cjbme.csbme.org/EN/Y2023/V42/I5/603

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