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| Study on Characteristics of 40 Hz-ASSR in Depressed Rats |
| Ren Zhengyu&, He Yuchen&, Liu Shuang*, Liu Xiaoya, Ke Yufeng, Chen Long, Ming Dong# |
| (Academy of Medical Engineering and Translational Medicine, Tianjin University, Tianjin 300072,China) |
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Abstract Depression has become a major public health problem endangering human health. At present, the diagnosis of depression mainly depends on patients' self-reports or filling in professional scales, which are judged by doctors and has the disadvantages of high misdiagnosis rate and poor consistency. Therefore, it is of great value and significance to find an accurate, efficient and convenient biomarker of depression. By comparing the difference of 40 Hz auditory steady-state response (ASSR) in the primary auditory cortex between the depression group and the control group, this study explored the feasibility of ASSR as a diagnostic target of depression, in order to provide ideas for the diagnosis and treatment of depression. In this work, 24 rats were randomly divided into depression model group (n=12) and normal control group (n=12). The model group was established by chronic unpredictable mild stress stimulation (CUMS) lasting for 8 weeks. By collecting and comparing three behavioral indicators of the two groups of rats before and after modeling, such as sugar water preference, forced swimming, open field experiment, we could judge whether the modeling was successful. Then, electrophysiological experiments were carried out to collect local field potential signals (LFPs) at the left and right primary auditory cortex of rats under 40 Hz click sound stimulation. The results showed that the 8-week depression modeling significantly reduced the sugar water preference rate(71.89±6.32 vs 87.65±3.54,P＜0.05)and open field movement distance of the model group(2 219±532 vs 2 930±315,P＜0.05), significantly increased the swimming rest time of the model group [ (31.53±5.31)s vs (96.18±13.16)s,P＜0.05], and there was also a significant difference in the behavioral post-test results between the two groups (P<0.05), which indicated an effective depression model had been established. Electrophysiological results showed that under click sound, the ITPC value of 40 Hz ASSR in both primary auditory cortex of the model group was lower than 0.6, significantly lower than that of the control group (ITPC > 0.8) (P < 0.05), and the evoked power also showed a downward trend. Based on the above results, this study found out that 40 Hz ASSR in the primary auditory cortex induced by click sound could be a potential diagnostic target for depression, which provided a certain reference for the auxiliary diagnosis and treatment of depression.
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Received: 28 February 2022
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Corresponding Authors:
*E-mail: shuangliu@tju.edu.cn
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| About author:: #Member, Chinese Society of Biomedical Engineering,&Co-first outhor |
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