微波消融有效消融体积模型实验研究

doi:10.3969/j.issn.0258-8021.2014. 01.08

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Abstract Temperature variation in ablated area and effective ablation volume are very important parameters for microwave ablation treatment. In order to provide reference for realtime assessment of ablation efficacy, in vitro porcine liver experiments were carried out to monitor tissue temperature and build effective microwave ablation volume models in this work. Microwave power of 40~70 W and ablation time of 300~600 s were chosen to perform total 112 microwave ablations. The microwave power of 70 W was used in the first group of experiments and temperature changes at sites 5, 10, 15 and 20 mm away from microwave antenna were recorded in realtime during ablation. In the second group of experiments, different combinations of power and time produced a series of data of short axis, long axis and volume. Results showed that the increase of temperature near the microwave antenna was more rapid. Temperature rise at 5 mm away from the antenna was 10 times faster than that at 20 mm away. Volume data of the ablation area was analyzed using 1stopt to build experimental models for the short axis, long axis and volume of the ablation zone. Consequently, the monitoring of temperature and utilization of effective volume models will contribute to the microwave ablation surgical planning and realtime ablation efficacy assessment.

Key words： microwave ablation ablation zone volume model surgical planning

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	ZHAO Jin Zhe¹QIAN Zhi Yu^1* LIU Jia²WU Jia Li¹WANG

Cite this article:

ZHAO Jin Zhe¹QIAN Zhi Yu^1* LIU Jia²WU Jia Li¹WANG. Experimental Study on Effective Microwave Ablation Volume Model[J]. journal1, 2014, 33(1): 51-56.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2014. 01.08 OR http://cjbme.csbme.org/EN/Y2014/V33/I1/51

［1］Liang Ping, Dong Baowei, Yu Xiaoling, et al. Prognostic factors for percutaneous microwave coagulation therapy of hepatic metastases ［J］. Am J Roentgenol, 2003, 181(5): 1319-1325.
［2］Simon CJ, Dupuy DE, MayoSmith WW. Microwave ablation: principles and applications ［J］. Radiographics, 2005, 25(Suppl 1): S69-S83.
［3］刘静, 邓中山. 肿瘤热疗物理学［M］. 北京：科学出版社, 2008: 8-9
［4］唐劲天. 肿瘤热疗生物学［M］. 北京：人民卫生出版社, 2010: 115-122
［5］Liang Ping, Yu Jie, Yu Xiaoling, et al. Percutaneous cooledtip microwave ablation under ultrasound guidance for primary liver cancer: a multicentre analysis of 1363 treatmentnaive lesions in 1007 patients in China ［J］. Gut, 2012, 61(7): 1100-1101.
［6］Liang Ping, Wang Yang, Yu XiaoLing, et al. Malignant liver tumors: treatment with percutaneous microwave ablationcomplications among cohort of 1136 patients ［J］. Radiology, 2009, 251(3): 933-940.
［7］Bhardwaj N, Strickland AD, Ahmad F, et al. Microwave ablation for unresectable hepatic tumours: clinical results using a novel microwave probe and generator ［J］. European Journal of Surgical Oncology(EJSO), 2010, 36(3): 264-268. 
［8］Wolf FJ, Grand DJ, Machan JT, et al. Microwave ablation of lung malignancies: effectiveness, CT findings, and safety in 50 patients ［J］. Radiology, 2008, 247(3): 871-879.［9］Castle SM, Salas N, Leveillee RJ. Initial experience using microwave ablation therapy for renal tumor treatment: 18-month followup ［J］. Urology, 2011, 〖STHZ〗77〖STBZ〗(4): 792-797.
［10］Yu Jie, Liang Ping, Yu Xiaoling, et al. Ultrasoundguided percutaneous microwave ablation of splenic metastasis: report of four cases and literature review ［J］. International Journal of Hyperthermia, 2011, 27(5): 517-22.
［11］李欣. 超声引导下微波消融治疗肝癌的研究进展［J］. 肿瘤学杂志, 2010,16(7): 523-526.
［12］Brace CL, Laeseke PF, van der Weide DW, et al. Microwave ablation with a triaxial antenna: results in ex vivo bovine liver ［J］. IEEE Transactions on Microwave Theory and Techniques, 2005, 53(1): 215-220.
［13］曹兵生, 董宝玮, 黎晓林, 等. 扩大微波凝固范围和改善凝固形状的实验研究［J］. 中华超声影像学杂志, 2006, 15(8): 621-623.
［14］孙媛媛, 梁萍, 董宝玮, 等. 水冷915 MHz与2450 MHz微波凝固离体猪肝的比较［J］. 中国医学影像技术, 2007, 23(2): 177-180.
［15］Brace CL, Laeseke PF, Sampson LA, et al. Microwave ablation with multiple simultaneously powered smallgauge triaxial antennas: Results from an in vivo swine liver model1 ［J］. Radiology, 2007, 244(1): 151-156.
［16］Yang Deshan, Converse MC, Mahvi DM, et al. Measurement and analysis of tissue temperature during microwave liver ablation ［J］. IEEE Transactions on Biomedical Engineering, 2007, 54(1): 150-155.
［17］Shi Wenyuan, Liang Ping, Zhu Qiang, et al. Microwave ablation: results with double 915 MHz antennae in ex vivo bovine Livers ［J］. European journal of radiology, 2011, 79(2): 214-217.
［18］Jones C, Badger S A, Ellis G. The role of microwave ablation in the management of hepatic colorectal metastases ［J］. The Surgeon, 2011, 9(1): 33-37.
［19］Kuang Ming, Lu Ming D, Xie Xiao Y, et al. Liver Cancer: Increased microwave delivery to ablation zone with cooledshaft antennaexperimental and clinical studies ［J］. Radiology, 2007, 242(3): 914-924.
［20］Wang Yang, Sun Yuanyuan, Feng Lei, et al. Internally cooled antenna for microwave ablation: results in ex vivo and in vivo porcine livers ［J］. European Journal of Radiology, 2008, 67(2): 357-361.
［21］Cheng Zhigang, Xiao Qiujin, Wang Yang, et al. 915MHz microwave ablation with implanted internal cooledshaft antenna: Initial experimental study in in vivo porcine livers ［J］. European Journal of Radiology, 2011, 79(1): 131-135.
［22］Liang Ping Wang Yang. Microwave ablation of hepatocellular carcinoma ［J］. Oncology, 2007, 72(Suppl 1): 124-131.
［23］Keangin P, Wessapan T, Rattanadecho P. Analysis of heat transfer in deformed liver cancer modeling treated using a microwave coaxial antenna ［J］. Applied Thermal Engineering, 2011, 31(16): 3243-3254.
［24］张烨，钱志余，郭金涛，等. 肿瘤微波热消融有效毁损区域温度场分布的仿真研究［J］. 生物物理学报, 2012, 28(9): 763-770.