Glioma Segmentation Based on Feature Selection of Multi-Modal MR Images
Cheng Juan1#, Zhang Chuya1, Liu Yu1#*, Li Chang1, Zhu Zhiqin2, Chen Xun3#
1(Department of Biomedical Engineering, Hefei University of Technology, Hefei 230009, China) 2(College of Automation, Chongqing University of Posts and Telecommunications, Chongqing 400065, China) 3(Department of Electronic Engineering and Information Science, University of Science and Technology of China, Hefei 230026, China)
Abstract Glioma segmentation based on multi-modal MR images plays a positive role for the diagnosis and treatment of tumors. It is known that different modalities of MR images can provide different properties of information representing pathological tissues. Currently, an increasing number of deep-learning-based glioma segmentation methods have been proposed to segment brain gliomas utilizing multi-modal MR images. However, these methods usually stack the original features derived from multi-modal MR images channel by channel, and roughly take the stacked features as inputs, leading to an inadequate feature mining and an unsatisfactory segmentation performance. To solve this problem, this paper proposed to segment three glioma regions with a two-stage segmentation scheme, with each stage having a feature selection module and a segmentation network. The first stage of the segmentation aimed to segment peripheral edema regions, while the second stage tried to segment necrosis/non-enhancing tumor and enhancing tumor regions. Besides, the first-stage segmentation results provided essential location information that would benefit for segmenting the other two tumor regions during the second stage. For each stage, a multi-modal feature selection module was designed to automatically extract effective and cross-modal-fused features from each modality of MR images, and then these features were sent to each following segmentation network. The segmentation network was composed of a V-Net and a variational autoencoder (VAE). Experiments were conducted on three public brain tumor datasets including BraTS2018, BraTS2019 and BraTS2020. Specifically, for dataset BraTS2018, the average Dice scores of the proposed method for segmenting the whole tumor (WT), the tumor core (TC), and the enhanced tumor (ET) regions reached 0.898, 0.854, and 0.818, respectively, while the Hausdorff95 distance of the proposed method for segmenting the aforementioned three regions reached 4.072, 6.179, and 3.763, respectively. As for dataset BraTS2019, the average Dice scores of the proposed method for segmenting the abovementioned three tumor regions reached 0.892, 0.839, and 0.800, respectively, while the corresponding Hausdorff95 distance of the proposed method can reach to 6.168, 7.077 and 3.807, respectively. As for dataset BraTS2020, the average Dice scores of the proposed method for segmenting the same three regions reached 0.896, 0.837, and 0.803, respectively, while the corresponding Hausdorff95 distance of the proposed method reached 6.223, 7.033, and 4.411, respectively. The results of the comparison experiments demonstrated the obvious superior performance of the proposed method in segmenting ET and TC regions, especially that the performance of ET segmentation was the best in BraTS2020. Owing to the proposed two-stage segmentation scheme, with each having a feature selection module followed by a segmentation network, the potentially cross-modality-fused features could be automatically extracted from each modality of MR images, thus the performance of segmenting the three tumor regions was significantly improved.
Cheng Juan#,Zhang Chuya,Liu Yu#*, et al. Glioma Segmentation Based on Feature Selection of Multi-Modal MR Images[J]. Chinese Journal of Biomedical Engineering, 2022, 41(5): 513-526.
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