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| Advances in Microneedle-Mediated Therapies for Superficial Tumors |
| Song Gao1,2, Liu Tianqi1,2, Zhang Xueya1,2, Tong Zaizai1,2,3, Jiang Guohua1,2,3* |
1(Department of Polymer Materials, College of Materials Science and Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China)
2(Institute of Smart Biomaterials, Zhejiang Sci-Tech University, Hangzhou 310018, China)
3(Zhejiang Mauritius Joint Research Center for Biomaterials and Tissue Engineering, Zhejiang Sci-Tech University, Hangzhou 310018, China) |
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Abstract As a new emerging approach, microneedle-based transdermal delivery system has the advantages of minimal invasion, painlessness, safety, efficiency, convenient usage and improvement of patient compliance. In the treatment of superficial tumors, microneedles can effectively pierce the stratum corneum of the skin, thereby promoting the loaded-drug to be penetrated and enriched on the tumor sites. The application of microneedles can have the drugs to avoid the clearance by the liver due to the first pass effect, prevent gastrointestinal side effects, and improve the utilization rate, exhibiting better therapeutic effect in comparison with intravenous administration and intratumoral injection under the same drug dose level. Combined with the new therapeutic strategies, including chemotherapy, photothermal therapy, photodynamic therapy, gene therapy and immunotherapy, the research progresses of microneedles for treatment on superficial tumors have been reviewed in this paper, aiming to promote the therapies of superficial tumors with minimally invasive and local precision drug delivery in the future.
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Received: 15 June 2020
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