Progress in Tissue Engineering Scaffolds Based on Polycaprolactone Fibers
Wu Xiaotong1,2 , He Er1,2 , Liu Laijun1,2 , Li Chaojing1,2* , Wang Lu1,2 , Wang Fujun1,2*
1 (College of Textiles,Donghua University,Shanghai 201620,China)2 (Key Laboratory of Textile Science & Technology,Ministry of Education,Shanghai 201620,China)
Abstract Polycaprolactone (PCL) is a kind of biocompatible,absorbable and easily modified polyester. Tissue engineering scaffolds based on PCL fibers are widely used because of their high specific surface area,good mechanical properties,and easy control of pore size,porosity and fiber orientation. In this paper,main application defects of PCL fiber scaffolds,such as poor cell affinity,slow degradation rate and low mechanical strength and the improvement methods were reviewed. At the same time,the latest development of tissue engineering scaffolds based on PCL fiber in the regeneration of skin,blood vessel,nerve,tendon,ligament and cartilage was summarized. It is shown that most of the current studies focused on improving cell-scaffold interaction and regulating the degradation behavior of scaffolds by introducing bioactive substances or drugs,or changing the physical structure of scaffolds by using different spinning processes and parameters to regulate the mechanical properties and cell-behavior induction of scaffolds. In addition,most of the studies are still staying in the laboratory stage. It is an important development direction in the future to promote tissue engineering scaffolds based on PCL fibers with the advantages of low cost and easy processing.
Key words ：
polycaprolactone
tissue engineering
fiber
scaffold
Received: 18 November 2019
[1] 江文诗,Gomez M P,Paez G,et al.数据之美——聚焦全球器官捐献发展趋势[J].中华移植杂志(电子版),2019,13(1):28-33.In vitro degradation of poly(caprolactone)/nha composites[J].J Nanomater,2014,2014:802435.in vitro study in peripheral nerve tissue engineering[J].J Biomed Mater Res A,2017,105(7):1960-1972.
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