基于聚己内酯纤维的组织工程支架研究进展

doi:10.3969/j.issn.0258-8021.2020.05.012

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Abstract Polycaprolactone (PCL) is a kind of biocompatible,absorbable and easily modified polyester. Tissue engineering scaffolds based on PCL fibers are widely used because of their high specific surface area,good mechanical properties,and easy control of pore size,porosity and fiber orientation. In this paper,main application defects of PCL fiber scaffolds,such as poor cell affinity,slow degradation rate and low mechanical strength and the improvement methods were reviewed. At the same time,the latest development of tissue engineering scaffolds based on PCL fiber in the regeneration of skin,blood vessel,nerve,tendon,ligament and cartilage was summarized. It is shown that most of the current studies focused on improving cell-scaffold interaction and regulating the degradation behavior of scaffolds by introducing bioactive substances or drugs,or changing the physical structure of scaffolds by using different spinning processes and parameters to regulate the mechanical properties and cell-behavior induction of scaffolds. In addition,most of the studies are still staying in the laboratory stage. It is an important development direction in the future to promote tissue engineering scaffolds based on PCL fibers with the advantages of low cost and easy processing.

Key words： polycaprolactone tissue engineering fiber scaffold

Received: 18 November 2019

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R318

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	Articles by authors
	Wu Xiaotong
	He Er
	Liu Laijun
	Li Chaojing
	Wang Lu
	Wang Fujun

Cite this article:

Wu Xiaotong,He Er,Liu Laijun, et al. Progress in Tissue Engineering Scaffolds Based on Polycaprolactone Fibers[J]. Chinese Journal of Biomedical Engineering, 2020, 39(5): 611-620.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021.2020.05.012 OR http://cjbme.csbme.org/EN/Y2020/V39/I5/611

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