无心跳供体肺支气管内气体三维流动的数值模拟研究

doi:10.3969/j.issn.0258-8021. 2014.03.09

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Abstract Nonheart beating donor (NHBD) lung is expected to be the most potential donor source for clinical lung transplantation, and the low temperature ventilation is normally thought to effectively protect the donor lung in vivo. A 3D asymmetric bronchial model with four levels was formed in this work; computational fluid dynamics (CFD) technique was adopted for investigating the 3D flow characteristics inside NHBD lung bronchia. Results show that there were some differences of dimensionless velocity distribution between inhaling and exhaling, the velocity distribution was also different on the left lung bronchus and the right lung bronchus sections. In particular, the dimensionless velocity of left lobar bronchus was 17 but the right upper lobar was 08. The flow ratios of left and right bronchia were 55% and 45%, respectively. The flow ratio of left inferior lobar bronchus was the largest one, about 35%. This is related to bifurcation angles and diameters changing with varied levels. The average pressure drop coefficients inside bronchia were also obtained here, which was the function of Re as 〖AKC-〗p〗∝Re－06. Because of the existence of asymmetric structure of bronchial and bifurcation space rotation angle, the gas flow in the bronchus became complicated, which is valuable for clinical and experimental study on NHBD lung in situ through cryopreservation.
〖KH2D〗
〖WTHZ〗Key words：〖WTBZ〗〖BP(〗┣┣（英）关键词┫┫〖BP)〗〖HT〗〖ST〗〖WT〗〖HJ〗〖HK〗

Key words： nonheart beating donor (NHBD) bronchia mechanical ventilation passive breathing numerical simulation

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	LIU Jing¹
	2 XU Yi^1#* LIU Dao Ping² ZHAO XiaoGang³

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LIU Jing^1,2 XU Yi^1#* LIU Dao Ping² ZHAO XiaoGang³. Simulation on 3D Flow Characteristics inside Bronchia of NonHeart Beating Donor Lung[J]. journal1, 2014, 33(3): 320-328.

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http://cjbme.csbme.org/EN/10.3969/j.issn.0258-8021. 2014.03.09 OR http://cjbme.csbme.org/EN/Y2014/V33/I3/320

［1］Gomez A, David, Varela U, et al. Present state of nonheartbeating lung donation ［J］. Current Opinion in Organ Transplantation, 2008, 13(6): 659-663.
［2］Masaru K, Isao M. Effective 6-hour preservation in nonheartbeating donor canine lungs with topical cooling: assessment from histopathological aspects ［J］. Surgery Today, 2005, 35: 389-395.
［3］Van WC, Neyrinck AP, Geudens N, et al. Retrograde flush following topical cooling is superior to preserve the nonheartbeating donor lung ［J］. European Journal of CardioThoracic Surgery, 2007, 31: 1125-1132. 
［4］Kutschka I, Sommer SP, Hohlfeld JM, et al. Insitu topical cooling of lung grafts: early graft function and surfactant analysis in a porcine single lung transplant model ［J］. European Journal of CardioThoracic Surgery, 2003, 24: 411-419.
［5］丁嘉安, 姜格宁. 肺移植［M］. 上海：上海科学技术出版社, 2008.
［6］Dougherty JC, Sinha S, Kibble F, et al. Intolerance of the ischemic lung to hypothermic ventilation ［J］. Journal Applied Physical, 1972, 32: 632-634.
［7］Van Raemdonck DE, Jannis NC, Rega FR, et al. External cooling of warm ischemic rabbit lungs after death ［J］. Ann Thoracic Surgery, 1996, 62: 331-337.
［8］Egan TM. Nonheartbeating donors in thoracic transplantation ［J］. Journal of Heart Lung Transplant, 2004, 23: 3-10.
［9］Takahiro O, Alicia C, Salvatore P, et al. Highflow endobronchial cooled humidified air protects nonheartbeating donor rat lungs against warm ischemia ［J］. Journal of Thoracic and Cardiovascular Surgery, 2006,
132: 413-419.
［10］彭富裕, 胥义, 赵晓刚, 等. 无心跳供体肺原位降温保护系统的研究［J］. 制冷学报, 2012, 33(4): 74-78. 
［11］Werner H, Modeling inhaled particle deposition in the human lung—a review ［J］. Journal of Aerosol Science, 2011, 42: 693-724. 
［12］朱蕾, 刘又宁, 钮善福. 临床呼吸生理学［M］. 北京人民卫生出版社, 2008.
［13］Weibel ER, Ewald R. Morphometry of the human lung ［J］. Anesthesiology, 1965, 26(3): 367. 
［14］Horsfield K, Dart G; Olson DE. Models of the human bronchial tree ［J］. Journal of Applied physiology, 1971, 31(2): 207-17.
［15］Calay RK, Kurujareon J, Holdo AE. Numerical simulation of respiratory flow patterns within human lung ［J］. Respiratory Physiology & Neurobiology (S1569-9048), 2002, 130(2): 201-221.
［16］梅岩艾, 王建军, 王世强. 生理学原理［M］. 北京:高等教育出版社, 2011.
［17］Luo HY, Liu Y. Modeling the bifurcating flow in a CTscanned human lung airway ［J］. Journal of Biomechanics, 2008, 41(12): 2681-2688.
［18］Slutsky A, Berdine G, Drasen. Steady flow in a model of human central airways ［J］. Journal of Applied Physiology, 1980, 49, 417-423.
［19］Snyder B, Olson DE. Flow development in a model airway bronchus ［J］. Journal of Fluid Mechanics, 1989, 207, 378-392.
［20］Grosse S, Schroeder W, Klaas M. Time resolved analysis of steady and oscillating flow in the upper human airways ［J］. Experiments in Fluids, 2007, 42(6): 955-970.