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Technological Progresses of the Magnetic Resonance Electrical Property Tomography of Human Tissues |
1 Biomedical Engineering Department, Southern Medical University, Guangzhou 510515, China
2 Bernard and Irene Schwartz Center for Biomedical Imaging, School of Medicine, New York University, New York, NY 10016, USA |
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Abstract It has been demonstrated that electrical properties, such as the conductivity and permitivity, are usually very different between healthy and tumor tissues. Therefore, the in vivo measurement of electrical properties may be a potential method for the early detection of cancers. In principle, the magnetic resonance imaging (MRI) system is the interaction between the nonionized electromagnetic field, including strong static magnetic field, gradient magnetic field, and radiofrequency field, and the human tissues, thus the information of electrical properties is definitely embedded inside the MRI. Recently developed
technigue of in vivo magnetic resonance electrical property tomography (MR EPT) of human tissues are exactly the
technigue for the in vivo extraction of electrical properties from tissues. This paper introduces the background of MR EPT, analytically deduces the quantitatively relationship between the MRI radiofrequency field and the electrical properties of tissues based on the Maxwell’s equations, which are the governing equations for the description of the behaviors of electromagnetic fields inside tissues. The efficacy, deficiency and potentials of the MR EPT technique at 3 T and 7 T are respectively analyzed according to the international updated progress. The preliminary clinical research of in vivo measurement of electrical properties of healthy and tumor tissues using MR EPT technique is summarized, showing the promising future of this cuttingedge technique.
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[1]Gabriel C, Gabriel S, Corthout E. The dielectric properties of biological tissues: I. Literature survey [J]. Phys Med Biol, 1996, 〖STHZ〗41〖STBZ〗(11): 2231-2249.
[2]Gabriel S, Lau RW, Gabriel C. The dielectric properties of biological tissues: II. Measurements in the frequency range 10 Hz to 20 GHz [J]. Phys Med Biol, 1996, 41(11): 2251-2269.
[3]Gabriel S, Lau RW, Gabriel C. The dielectric properties of biological tissues: III. Parametric models for the dielectric spectrum of tissues [J]. Phys Med Biol, 1996, 41(11): 2271-2293.
[4]Joines WT, Zhang Yang, Li Chenxing, et al. The measured electrical properties of normal and malignant human tissues from 50 to 900 MHz [J]. Med Phys, 1994, 21(4): 547-550.
[5]Lu Yongjun, Li Baomin, Xu Jianping, et al. Dielectric properties of human glioma and surrounding tissue [J]. Int J Hyperthermia, 1992, 8(6): 755-760.
[6]Surowiec AJ, Stuchly SS, Barr JB, et al. Dielectric properties of breast carcinoma and the surrounding tissues [J]. IEEE Trans Biomed Eng, 1988, 35(4): 257-263.
[7]Fear EC, Xu Li, Susan CH, et al. Confocal microwave imaging for breast cancer detection: localization of tumors in three dimensions [J]. IEEE Trans Biomed Eng, 2002, 49(8): 812-822.
[8]Haemmerich D, Staelin ST, Tsai JZ, et al. In vivo electrical conductivity of hepatic tumours [J]. Physiol Meas, 2003, 24(2): 251-260.
[9]Smallwood RH, Keshtkar A, Wilkinson BA, et al. Electrical impedance spectroscopy (EIS) in the urinary bladder: the effect of inflammation and edema on identification of malignancy [J]. IEEE Trans Med Imaging, 2002, 21(6): 708-710.
[10]Stuchly MA, Stuchly SS. Coaxial line reflection methods for measuring dielectric properties of biological substances at radio and microwave frequenciesa review [J]. IEEE Transactions on Instrumentation and Measurement, 1980, 29(3): 176-183.
[11]Venkatesh M, Raghavan G. An overview of dielectric properties measuring techniques [J]. Canadian Biosystems Engineering, 2005, 47(7): 15-30.
[12]Henderson RP, Webster JG. An impedance camera for spatially specific measurements of the thorax [J]. IEEE Transactions on Biomedical Engineering, 1978, 25(3): 250-254.
[13]Barber DC, Brown BH. Applied Potential Tomography [J]. Journal of physics E Scientific instruments, 1984, 17(9): 723-733.
[14]董秀珍. 生物电阻抗成像研究的现状与挑战 [J]. 中国生物医学工程学报, 2008, 27(5): 641-649.
[15]Liston AD, Bayford RH, Tidswell AT, et al. A multishell algorithm to reconstruct EIT images of brain function [J]. Physiol Meas, 2002, 23(1): 105-119.
[16]Woo EJ, Lee SY, Mun CW. Impedance tomography using internal current density distribution measured by nuclear magnetic resonance [C] //Bookstein FL, Duncan JS, Lange N, Wilson DC, eds. Mathematical Methods in Medical Imaging III. San Diego, CA: SPIE, 1994: 377-385.
[17]Joy ML, Scott GC, Henkelman RM. In vivi detection of applied electric currents by magnetic resonance imaging [J]. Magnetic Resonance Imaging, 1989, 7(1): 89-94.
[18]Li Xu, He Bin. Multiexcitation magnetoacoustic tomography with magnetic induction for bioimpedance imaging [J]. IEEE Trans Med Imaging, 2010, 29(10): 1759-1767.
[19]Haacke EM, Petropoulos LS, Nilges EW, et al. Extraction of conductivity and permittivity using magnetic resonance imaging [J]. Phys Med Biol, 1991, 36(6): 723-734.
[20]Wen Han. Noninvasive quantitative mapping of conductivity and dielectric distributions using RF wave propagation effects in highfield MRI [C] //Yaffe MJ, Antonuk LE, eds. Physics of Medical Imaging. San Diego, CA: SPIE, 2003: 471-477.
[21]Katscher U, Voigt T, Findeklee C, et al. Determination of Electric Conductivity and Local SAR Via B1 Mapping [J]. Medical Imaging, IEEE Transactions on, 2009, 28(9): 1365-1374.
[22]Sled JG, Pike GB. Standingwave and RF penetration artifacts caused by elliptic geometry: an electrodynamic analysis of MRI [J]. IEEE Transactions on Medical Imaging, 1998, 17(4): 653-662.
[23]Zhang Xiaotong, Zhu Shanan, He Bin. Imaging Electric Properties of Biological Tissues by RF Field Mapping in MRI [J]. IEEE Transactions on Medical Imaging, 2010, 29(2): 474-481.
[24]Stehning C, Voigt TR, Katscher U. Realtime conductivity mapping using balanced SSFP and phasebased reconstruction [C] //Proceedings of the 19th Annual Meeting of the International Society for Magnetic Resonance in Medicine. Montréal: ISMRM, 2011: 128.
[25]Voigt T, Katscher U, Doessel O. Quantitative conductivity and permittivity imaging of the human brain using electric properties tomography [J]. Magnetic Resonance in Medicine, 2011, 66(2): 456-466.
[26]Seo JK, Kim MO, Lee J, et al. Error Analysis of Nonconstant Admittivity for MRBased Electric Property Imaging [J]. IEEE Transactions on Medical Imaging, 2012, 31(2): 430-437.
[27]Seo JK, Kim DH, Lee J, et al. Electrical tissue property imaging using MRI at dc and Larmor frequency [J]. Inverse Problems, 2012, 28(8): 1-26.
[28]Sodickson DK, Alon Leeor, Deniz CM, et al. Local Maxwell tomography using transmitreceive coil arrays for contactfree mapping of tissue electrical properties and determination of absolute RF phase[C]//Proceedings of the 20th Annual Meeting of the International Society for Magnetic Resonance in Medicine. Melbourne: ISMRM, 2012: 387.
[29]Van Lier AL, Brunner DO, Pruessmann KP, et al. B1(+) phase mapping at 7 T and its application for in vivo electrical conductivity mapping [J]. Magn Reson Med, 2012, 〖STHZ〗67〖STBZ〗(2): 552-561.
[30]Liu Jiaen, Zhang Xiaotong, Van de Moortele PF, et al. Determining electrical properties based on B1 fields measured in an MR scanner using a multichannel transmit/receive coil: a general approach [J]. Phys Med Biol, 2013, 58(13): 4395-4408.
[31]Zhang Xiaotong, Van de Moortele PF, Schmitter S, et al. Complex B1 mapping and electrical properties imaging of the human brain using a 16-channel transceiver coil at 7T [J]. Magnetic Resonance in Medicine, 2013, 69(5): 1285-1296.
[32]Ibrahim TS, Mitchell C, Abraham R, et al. Indepth study of the electromagnetics of ultrahighfield MRI [J]. NMR Biomed, 2007, 20(1): 58-68.[33]Collins CM, Wang Zhangwei. Calculation of radiofrequency electromagnetic fields and their effects in MRI of human subjects [J]. Magnetic Resonance in Medicine, 2011, 65(5): 1470-1482.
[34]Bulumulla SB, Lee SK, Yeo DTB. Conductivity and permittivity imaging at 30 t [J]. Concepts in Magnetic Resonance Part B: Magnetic Resonance Engineering, 2012, 41B(1): 13-21.
[35]Hoult DI. The principle of reciprocity in signal strength calculations—A mathematical guide [J]. Concepts in Magnetic Resonance, 2000, 124): 173-187.
[36]Voigt T, Homann H, Katscher U, et al. Patientindividual local SAR determination: In vivo measurements and numerical validation [J]. Magnetic Resonance in Medicine, 2012, 68(4): 1117-1126.
[37]Yarnykh VL. Actual flipangle imaging in the pulsed steady state: a method for rapid threedimensional mapping of the transmitted radiofrequency field [J]. Magn Reson Med, 2007, 57(1): 192-200.
[38]Van de Moortele PF, Snyder C, DelaBarre L, et al. Calibration tools for RF shim at very high field with multiple element RF coils: from ultra fast local relative phase to absolute magnitude B1+mapping[C]//Proceedings of the 15th Annual Meeting of the International Society for Magnetic Resonance in Medicine. Berlin: ISMRM, 2007: 1676.
[39]Adriany G, Van de Moortele PF, Ritter J, et al. A geometrically adjustable 16-channel transmit/receive transmission line array for improved RF efficiency and parallel imaging performance at 7 Tesla [J]. Magn Reson Med, 2008, 59(3): 590-597.
[40]Van Lier AL, Hoogduin JM, Polders DL, et al. Electrical conductivity imaging of brain tumours [C]//
Proceedings of the 19th Scientific Meeting of the International Society for Magnetic Resonance in Medicine. Montréal: ISMRM, 2011: 4464.
[41]Katscher U, Djamshidi K, Voigt T, et al. Estimation of breast tumor conductivity using parabolic phase fitting [C]//Proceedings of the 20th Scientific Meeting of the International Society for Magnetic Resonance in Medicine. Melbourne: ISMRM, 2012: 3482.
[42]Bulumulla SB, Hancu I. Breast Permittivity Imaging [C] //Proceedings of the 20th Scientific Meeting of the International Society for Magnetic Resonance in Medicine. Melbourne: ISMRM, 2012: 2532.
[43]Voigt T, Schuster A, Ishida M, et al. Conductivity imaging of an ischemic pig heart model using electric properties tomography [C]//Proceedings of the 20th Scientific Meeting of the International Society for Magnetic Resonance in Medicine. Melbourne, Australia: ISMRM, 2012: 3483.
[44]Van Lier A, Van der Kolk AG, Brundel M, et al. Electrical conductivity in ischemic stroke at 70 Tesla: A Case Study [C] //Proceedings of the 20th Scientific Meeting of the International Society for Magnetic Resonance in Medicine. Melbourne: ISMRM, 2012: 3484.
[45]Stehning C, Voigt T, Karkowski P, et al. Electric Properties Tomography (EPT) of the Liver in a Single Breathhold Using SSFP[C]//Proceedings of the 20th Scientific Meeting of the International Society for Magnetic Resonance in Medicine. Melbourne, Australia: ISMRM, 2012: 386.
[46]Balidemaj E, Van Lier AL, Nederveen AJ, et al. Feasibility of EPT in the Human Pelvis at 3T[C]//
Proceedings of the 20th Scientific Meeting of the International Society for Magnetic Resonance in Medicine. Melbourne: ISMRM, 2012: 3468.
[47]Balidemaj E, Van Lier AL, Crezee J, et al. Determining the patientspecific conductivity of pelvic tumors for use in Hyperthermia Treatment Planning[C]Proceedings of the 21st Scientific Meeting of the International Society for Magnetic Resonance in Medicine. Salt Lake City: ISMRM, 2013: 4178.
[48]Shin J, Kim MJ, Lee J, et al. Coil combine for conductivity mapping of breast cancer[C]//Proceedings of the 21st Scientific Meeting of the International Society for Magnetic Resonance in Medicine. Salt Lake City: ISMRM, 2013: 4180.
[49]Oh TI, Jeong WC, McEwan A, et al. Feasibility of magnetic resonance electrical impedance tomography (MREIT) conductivity imaging to evaluate brain abscess lesion: In vivo canine model [J]. Journal of Magnetic Resonance Imaging, 2013, 38(1): 189-197.
[50]Kim MO, Choi N, Shin J, et al. Phase unbanding in bSSFP for liver conductivity imaging at 30T [C] // Editorial board, eds. Proceedings of the 21st Scientific Meeting of the International Society for Magnetic Resonance in Medicine. Salt Lake City: ISMRM, 2013: 4173.
[51]Bottomley PA, Hardy CJ, Argersinger RE, et al. A Review of1H Nuclear Magnetic Resonance Relaxation in Pathology: Are T1 and T2 diagnostic? [J]. Medical Physics, 1987, 14(1): 1-37.
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