Effects of Fibrous Scaffolds Structure on Cell Behavior
Li Qiwei1, Li Chaojing1, Wang Fujun1,2*, Ding Wen1, Hu Sihan1, Wang Lu1,2
1 College of Textiles, Donghua University, Shanghai 201620, China 2 Key Laboratory of Textile Science & Technology, Ministry of Education, Shanghai 201620, China
Abstract：Effective strategies to guide cell growth are critical for the development of engineered tissues,and the surface morphology and properties of the biomaterials have appreciable impact on the biocompatibility and biological function, thus the regulation of cell behaviors can provide theoretical supports for developing biocompatible tissue engineering scaffolds. The fibrous scaffolds fabricated by electrospinning could mimic the network structure of the natural extracellular matrix (ECM), supporting cell attachment and guiding tissue formation, therefore fabricating micro- or nanofibers scaffolds are becoming of great interest in the area of biomaterials and tissue engineering. The effect of structural parameters of electrospun scaffolds on the cell behavior was reviewed in this paper, including fiber diameter, pore size, and fiber arrangement. The perspective of fibrous scaffolds and the current improved electrospinning methods for preparing different fibrous structures were also summarized.
李奇薇,李超婧,王富军,丁雯,胡思寒,王璐. 纤维基组织工程支架结构对细胞行为的影响[J]. 中国生物医学工程学报, 2018, 37(3): 372-379.
Li Qiwei, Li Chaojing, Wang Fujun, Ding Wen, Hu Sihan, Wang Lu. Effects of Fibrous Scaffolds Structure on Cell Behavior. Chinese Journal of Biomedical Engineering, 2018, 37(3): 372-379.
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