The Influence of Transcranial Alternating Current Stimulation on Mental Rotation
Dong Guoya1*, Shi Jing1, Yang Hui1, Liu Ye1, Wu Zuhe2, Chen Xiaogang3
1Department of Biomedical Engineering, School of Electrical Engineering, Hebei University of Technology, Tianjin 300130, China 2Department of Engineering Physics, Tsinghua University, Beijing 100084, China 3Institute of Biomedical Engineering, Chinese Academy of Medical Sciences and Peking Union Medical College, Tianjin 300192, China
Abstract：Transcranial alternating current stimulation (tACS) is a new non-invasive technology that applies weak electrical stimulation on the scalp to regulate neural activity. It has been confirmed that tACS can regulate spontaneous brain rhythm and influence cognitive process. Mental rotation is an important benchmark to measure spatial cognitive ability by imaging rotate object or itself. This study used mental rotation experimental paradigm to explore the effects of tACS on the mental rotation cognitive, the main evaluation indexes were behavioral performance and electrophysiological parameters like event related potential (ERP) and event related desynchronization (ERD). Behavioral results showed that the alpha tACS significantly reduced the reaction time(P<0.05), and with the image rotation angle increasing, the reaction time increased first and then decreased. Compared the mental rotation related negative wave between control group and stimulation group, we found that the RRN amplitude of stimulation group was lower than that of control group (stim vs sham, P<0.05), and it decreased first and then increased with the rotation angel increasing. The time-frequency analysis showed that the event related desynchronization in alpha and beta bands of stimulation group was weaker than that of control group (stim vs sham, P<0.05), and it appeared earlier than that of control group, indicating that tACS reduced the level of brain activation based on the earlier results that ERD is related to brain activation level. These results implied that tACS could improve the mental rotation ability and was potential in becoming a new way to improve the spatial cognitive ability.
董国亚, 石静, 杨慧, 刘晔, 吴祖河, 陈小刚. 经颅交流电刺激对心理旋转认知过程的影响[J]. 中国生物医学工程学报, 2017, 36(5): 565-572.
Dong Guoya, Shi Jing, Yang Hui, Liu Ye, Wu Zuhe, Chen Xiaogang. The Influence of Transcranial Alternating Current Stimulation on Mental Rotation. Chinese Journal of Biomedical Engineering, 2017, 36(5): 565-572.
[1] Antal A, Paulus W. Transcranial alternating current stimulation (tACS)[J]. Frontiers in Human Neuroscience, 2013, 7:317. [2] Riecke L, Formisano E, Herrmann CS, et al. 4-Hz transcranial alternating current stimulation phase modulates hearing[J]. Brain Stimulation, 2015, 8(4):777-783. [3] Janik AB, Rezlescu C, Banissy MJ. Enhancing anger perception with transcranial alternating current stimulation induced gamma oscillations[J]. Brain Stimulation, 2015, 8(6):1138-1143. [4] Westerberg CE, Florczak SM, Weintraub S, et al. Memory improvement via slow-oscillatorystimulation during sleep in older adults[J]. Neurobiology of Aging, 2015, 36(9):2577-2586. [5] Vosskuhl J, Huster RJ, Herrmann CS. Increase in short-term memory capacity induced by down-regulating individual theta frequency via transcranial alternating current stimulation[J]. Frontiers in Human Neuroscience, 2015, 9:257. [6] Pahor A, Jaušovec N. The effects of theta transcranial alternating current stimulation (tACS) on fluid intelligence[J]. International Journal of Psychophysiology, 2014, 93(3):322-331. [7] Wach C, Krause V, Molladze V, et al. Effects of 10Hz and 20Hz transcranial alternating current stimulation on motor functions and motor cortical excitability [J]. Behavioural Brain Research, 2013, 241(2):1-6. [8] Jaušovec N, Jaušovec K. Increasing working memory capacity with theta transcranial alternatingcurrent stimulation (tACS)[J]. Biological Psychology, 2014, 96(1):42-47. [9] Shepard R and Metzler J. Mental rotation of three-dimensional objects[J]. Science, 1971, 171(3972): 701-703. [10] Sladky R, Stepniczka I, Boland E, et al. Neurobiological differences in mental rotation and instrument interpretation in airline pilots[J]. Scientific Reports, 2016, 6:28104. [11] Osuagwu BA, Vuckovic A. Similarities between explicit and implicit motor imagery in mental rotation of hands: An EEG study[J]. Neuropsychologia,2014,65:197-210. [12] Heil M. The functional significance of ERP effects during mental rotation[J]. Psychophysiology,2002,39(5):535-545. [13] Nico D, Daprati E, Rigal F, et al. Left and right recognition in upper limb amputees[J]. Brain, 2004,127(1): 120-132. [14] Shepard RN, Cooper LA. Mental images and their transformations.[J]. American Journal of Psychology, 1983,4:31-47. [15] Pfurtscheller G, Scherer R, Müller-Putz GR, et al. Short-lived brain state after cued motor imagery in naive subjects[J]. European Journal of Neuroscience, 2008,28(7):1419-1426. [16] Bourrelier J, Kubicki A, Rouaud O, et al. Mental rotation as an indicator of motor representation in patients withmild cognitive impairment[J]. Frontiers in Aging Neuroscience, 2015, 7:238. [17] Chen X, Bin G, Gao X. Effects of stimulus views on mental rotation of hands: an event-related potential study[C]//Proceedings of Foundations and Practical Applications of Cognitive Systems and Information Processing.Berlin: Springer, 2014,215: 1-14. [18] Date S, Kurumadani H, Watanabe T, et al. Transcranial direct current stimulation can enhance ability in motor imagery tasks[J]. Neuroreport, 2015, 26(11):613-617. [19] Chen Xiaogang, Bin Guangyu, Daly I, et al. Event-related desynchronization(ERD) in the alpha band during a hand mental rotation task[J]. Neuroscience Letters, 2013,541(1):238-242. [20] Núñez-Peña MI, Aznar-Casanova J A. Mental rotation of mirrored letters: evidence from event-related brain potentials[J]. Brain and Cognition, 2009,69(1):180-187. [21] Gert Pfurtscheller AS. Mu rhythm (de)synchronization and EEG single-trial classification of different motor imagery tasks[J]. NeuroImage, 2006, 31(1):153-159.
