Abstract：The aim of this study was to investigate the changes of resting state EEG network structure caused by mental fatigue, and the influence of physical fatigue on the mental fatigue-related EEG network. Two-back task and cycling were used to induce mental fatigue and physical fatigue, respectively. Twenty channels of resting state EEG of 10 subjects were collected under 4 different fatigue conditions. EEG networks were obtained by calculating the partial directed coherence (PDC) causality between two arbitrary nodes and refined by comparing to a threshold. Only those links significantly higher than the threshold would be reserved, while others dismissed. After a comparison among the four EEG networks, a mental fatigue-related specific EEG network structure in N-back experiments was identified, in which FP2 was the hub while almost other channels had a link with it. The network structure was very stable, and its corresponding linking strength 4.0603 and 4.1421 in two fatigue state, which would not be influenced by physical fatigue. Therefore, this study identified an independent and stable functional network related to mental fatigue. The result provided a new perspective on the neural mechanism of mental fatigue and the relationship between mental fatigue and physical fatigue.
孟桂芳, 许敏鹏, 张春翠, 何 峰, 綦宏志, 明 东. 一种与N-Back诱发脑力疲劳相关的特异性脑电网络结构[J]. 中国生物医学工程学报, 2017, 36(2): 143-149.
Meng Guifang, Xu Minpeng, Zhang Chuncui, He Feng, Qi Hongzhi, Ming Dong. A Specific EEG Network Structure Related to Mental Fatigue Induced by N-back. Chinese Journal of Biomedical Engineering, 2017, 36(2): 143-149.
[1] Grandjean E. Fatigue in industry [J]. Br J Ind Med, 1979, 36(3): 175-186. [2] Faber LG, Maurits NM, Lorist MM. Mental fatigue affects visual selective attention [J]. PLoS ONE, 2012, 7(10): 48073- 48073. [3] Shortz AE, Van DS, Mehta RK. Neural correlates of physical and mental fatigue [C] //Beringer DB, eds. Proceedings of the Human Factors and Ergonomics Society Annual Meeting. New York: Sage Publications, 2012, 56(1): 2172-2176. [4] Zhao Chunlin, Zhao Min, Liu Jianpin, et al. Electroencephalogram and electrocardiograph assessment of mental fatigue in a driving simulator [J]. Accid Anal Prev, 2012, 45: 83-90. [5] Chieh TC, Mustafa MM, Hussain A, et al. Development of vehicle driver drowsiness detection system using electrooculogram (EOG) [J]. Computers, Communications & Signal Processing with Special Track on Biomedical Engineering, 2005,1: 165-168. [6] Muthalib M, Kan B, Nosaka K, et al. Oxygen Transport to Tissue XXXV [M]. New York:Springer, 2013: 73-79. [7] St. John M, Kobus DA, Morrison JG, et al. Overview of the DARPA augmented cognition technical integration experiment [J]. International Journal of Human-Computer Interaction, 2004, 17(2): 131-149. [8] K thner I, Wriessnegger SC, Müller-Putz GR, et al. Effects of mental workload and fatigue on the P300, alpha and theta band power during operation of an ERP (P300) brain-computer interface [J]. Biological psychology, 2014, 102: 118-129. [9] Buzsaki G. Rhythms of the Brain[M]. New York: Oxford University Press, 2006:52-53. [10] 孙俊峰,洪祥飞,童善保. 复杂脑网络研究进展:结构、功能、计算与应用 [J]. 复杂系统与复杂性科学, 2011, 7(4): 74-90. [11] 王春方,孙长城,张希,等. 基于偏定向相干性(PDC)的脑卒中后抑郁症患者脑网络研究 [J]. 中国生物医学工程学报, 2015, 34(4): 385-391. [12] Hurtado JM, Rubchinsky LL, Sigvardt KA. Statistical method for detection of phase-locking episodes in neural oscillations [J]. Journal of Neurophysiology, 2004, 91(4): 1883-1898. [13] Sun J, Small M. Unified framework for detecting phase synchronization in coupled time series [J]. Physical Review E, 2009, 80(4): 046219-046219. [14] 黄亮,吴超华,高小榕. 基于自回归模型和相位斜率指数的动态脑连接分析 [J]. 中国生物医学工程学报, 2016, 35(1): 1-9. [15] Granger CWJ. Investigating causal relations by econometric models and cross-spectral methods [J]. Econometrica, 1969, 37(3): 424-438. [16] Tanaka M, Mizuno K, Tajima S, et al. Central nervous system fatigue alters autonomic nerve activity [J]. Life Sciences, 2009, 84(7): 235-239. [17] Lorist MM, Kernell D, Meijman TF, et al. Motor fatigue and cognitive task performance in humans [J]. The Journal of physiology, 2002, 545(1): 313-319. [18] Mehta RK, Agnew MJ. Effects of concurrent physical and mental demands for a short duration static task [J]. Int J Ind Ergonom, 2011, 41:488-493. [19] Ridderinkhof KR, Ullsperger M, Crone EA, et al. The role of the medial frontal cortex in cognitive control [J].Science, 2004, 306(5695): 443-447. [20] Gao Qing, Duan Xujun, Chen Huafu. Evaluation of effective connectivity of motor areas during motor imagery and execution using conditional Granger causality [J]. Neuroimage, 2011, 54(2): 1280-1288.
