The Construction of Pathogenic Plasmodium Molecular Functional Annotation Secondary Database
Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China
Abstract：This research is intended to annotate functions of the molecules from highthroughput experimental data produced in the study of pathogenic plasmodium molecular mechanism. J2EE, MySQL, MVC architecture, Web Services and Hibernate techniques were applied to construct a secondary database (PlasmoFADB). Fisher's exact test was utilized for enrichment analysis of Gene Ontology and Pathway. Graphviz tool was used to provide a graphic description for protein-protein interaction. The PlasmoFADB provides a variety of molecular annotation types and displays the annotation results of Gene Ontology, Pathway and PPI with graphic interface. The establishment of the database is a valuable tool to understand the gene functions, signaling pathway in pathogenic plasmodium and helpful for its malaria vaccine antigen screening.
