Abstract：In order to analyze the influence of magnetic parameters on capture efficiency, a two phase CassonNewton model was developed to describe magnetic drug flowage in blood based on blood and rectangular magnet properties. The motion of magnetic nanoparticles under magnetic force and fluid force in blood vessel was analyzed, theoretic formulation of blood vessel 3D capture efficiency and further propose optimization model for capture drug volume was obtained to improve drug efficacy. Blood velocity and capture efficiency of Casson-Newton model, Newton model and Casson model were simulated by Matlab and compared to reveal the variation of capture drug volume, and the effects of particle radius, magnetic material radius ratio, magnetic field strength, distance between magnet and blood vessel, vessel radius, and other parameters on capture efficiency. According to the analysis results, the Non-Newton multiphase model performed system property better, the capture efficiency of Casson-Newton model was 4% higher than the two other models, and the capture drug volume reached maximum when magnetic materials radius ratio was 0.75 .
张勇全1王帅2吴强2王石刚1* 刘利1. 基于非牛顿流体多相流的磁性药物靶向给药捕获效率分析[J]. 中国生物医学工程学报, 2012, 31(1): 96-102.
ZHANG Yong Quan WANG Shuai2WU Qiang2 WANG ShiGang1*LIU Li1. Research on Capture Efficiency of Targeting Magnetic Drug Target Delivery Based on Non-Newton Fluid Multiphase Flow. journal1, 2012, 31(1): 96-102.
