40 Hz 暂态听觉诱发电位中潜伏期成分的引出分析

doi:10.3969/j.issn.0258-8021. 2013. 05.05

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摘要常规方式下听觉诱发电位（AEP）的一些成分（如P_b）的出现和稳定程度与刺激率有关，但是刺激率的提高受到AEP潜伏期的制约，两者的卷积效应导致暂态AEP无法直接获取。连续循环平均去卷积（CLAD）和多刺激率稳态平均去卷积（MSAD）是提取高刺激率下暂态AEP的两种新方法。由于两种方法的计算原理和实验范式不同，需要通过充分的实验评估其性能。本研究采用这两种去卷积技术获取了11例正常成年人的40 Hz暂态AEP，并和常规（5 Hz）AEP对照。结果发现40 Hz高刺激率下暂态AEP主要波形的引出率均为100%（常规AEP的N_b和P_b的引出率分别为72.73%和54.55%）；潜伏期的变异系数为6.57%（常规方式11.18%）；个体AEP与总体平均之间的相关系数为0.87（常规方式0.70）。上述结果表明，与常规方法相比，40 Hz时去卷积技术得到的暂态AEP的主要成分可以更稳定地被引出，在应用上更具优势。

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	朱程王涛黄江华詹长安谭小丹^*

关键词 ：听觉诱发电位, 40 Hz高刺激率, 去卷积

Abstract：Stimulusrate will affect some components of AEPs, typically P_bfor instance, which demonstrates an unstable characteristic in terms of elicitation at different stimulus rates. In practice, increasing stimulus rate has to be restricted to prevent the AEPs from overlapping. Two newly developed deconvolution techniques, so called continuous loop averaging deconvolution (CLAD) and multirate steadystate averaging deconvolution (MSAD) have been proposed to retrieve high rate AEP. As the computational theory and experimental paradigm are different for the two methods, it is thus in need of adequate experimental evaluation for high rate AEPs. This study investigated the elicitation of the deconvolved AEPs at 40 Hz sampled from eleven healthy adults in comparison with the conventional AEP at 5 Hz. Results show that the main components of 40 Hz transient AEPs can be fully elicited, while the elicitation rate for conventional AEPs is 72.73% for N_b, and 54.55% for P_b; likewise the comparison with mean variable coefficient is 6.57% vs. 11.18%, and the correlation coefficient is 0.87 vs 0.70. These results indicate the promising application of the two deconvolution techniques, and suggest that the main components of 40 Hz transient AEPs can be of substantial advantage over the conventional one.

Key words： auditory evoked potential 40 Hz high stimulus rate deconvolution

基金资助:国家自然科学基金（61172033，61271154）

引用本文:

朱程王涛黄江华詹长安谭小丹^*. 40 Hz 暂态听觉诱发电位中潜伏期成分的引出分析[J]. 中国生物医学工程学报, 2013, 32(5): 539-545.
ZHU Cheng WANG Tao HUANG Jiang Hua ZHAN Chang An TAN Xiao Dan^*. Elicitation Analysis for the 40 Hz Transient Auditory Evoked Potential. journal1, 2013, 32(5): 539-545.

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http://cjbme.csbme.org/CN/10.3969/j.issn.0258-8021. 2013. 05.05 或 http://cjbme.csbme.org/CN/Y2013/V32/I5/539

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