Abstract：In this work heparin–conjugating phenylalanine was linked to chloromethyl resin to prepare a new, safe, nontoxic adsorbent for endotoxin clearance. The optimal experimental conditions were determined by changing the amounts of reactants, reaction time and pH value. The performance of the heparinconjugating phenylalanine adsorbent were studied under the conditions of being in water and blood plasma, different initial concentration of endotoxin and the different lasting time. Additionally blood compatibility of the absorbent was evaluated. In dialyzing imitation experiments in water and in rabbit plasma, the endotoxin concentration was reduced to a low level after 2 hours of absorbent exposure. The maximum clearance rate was up to 79% and 72% in water and in the plasma respectively. The influence of the absorbent upon the concentrations of other substances in the blood was below 10%, showing excellent blood compatibility
靳欣欣 王翔* 毛金春 唐福州 熊延连. 肝素连接苯丙氨酸血液净化材料去除内毒素的研究[J]. 中国生物医学工程学报, 2013, 32(3): 348-355.
JIN Xin Xin1 WANG Xiang1* MAO Jin Chun1 TANG Fu Zhou1 XIONG Yan Lian1. Research of HeparinConjugating Phenylalanine Blood Purification Material to Remove Endotoxin. journal1, 2013, 32(3): 348-355.
