Fibrosis and Inflammatory Activity Analysis of Chronic Hepatitis C Based on Random Forest
Cai Jiaxin1* ,Qiu Xuan2,Huang Zhili1,Luo Ronglan1
1(School of Applied Mathematics, Xiamen University of Technology, Xiamen 361024, Fujian, China) 2(Department of Information, The 180th Hospital of PLA, Quanzhou 362000, Fujian, China)
Abstract：In order to predict the fibrosis stage and inflammatory activity grade of chronic hepatitis C, an auto-grading system based on two-stage random forest was proposed in this paper. Firstly, the feature importance of each serological index was obtained by learning the first stage random forest to evaluate its relevance to fibrosis stage and inflammatory activity grade. Secondly, the serological indices whose feature importance were above the predetermined threshold were chosen for the next classification step. Finally, the second stage random forest based on the chosen features was employed for determining the fibrosis stage and inflammatory activity grade. The proposed method has been tested on 123 clinical data of chronic hepatitis C based on serological indexes. Experimental results showed that the classification accuracy of fibrosis stage, fibrosis stage S4 and inflammatory activity grade are 68.29%, 100% and 73.17%. At last the most important serological indexes related to the fibrosis stage and inflammatory activity level ofchronic hepatitis C were determined as total cholesterol, HDL, ALT and AST. Experimental results demonstrated that the proposed method has the advantages of high recognition accuracy and low cost to get examination results and perform calculations, which makes it helpful for clinical diagnosis of chronic hepatitis C.
蔡加欣,邱璇,黄智力,骆榕澜. 基于随机森林的慢性丙型肝炎纤维化和活动度分析[J]. 中国生物医学工程学报, 2018, 37(5): 553-559.
Cai Jiaxin,Qiu Xuan,Huang Zhili,Luo Ronglan. Fibrosis and Inflammatory Activity Analysis of Chronic Hepatitis C Based on Random Forest. Chinese Journal of Biomedical Engineering, 2018, 37(5): 553-559.
